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Table 6

Crystallized mannitol based DPI formulations.

Drug	Method	Key ingredients	PSD (μm)	Device and flow rate (l/min)	% FPF	References
SS	ASC	Mannitol and acetonewater (95 : 5)		Aerolizer and 92		[45]
SS	ASC	Mannitol and ethanolwater (90 : 10)		Aerolizer and 92		[46]
SS	ASC	Mannitol and ethanolacetone (40 : 40)	-	Aerolizer and 92		[47]
SS	CC	Mannitol 20%, w/v, and deionized water	-	Aerolizer and 92		[20]
SS	ASC	MannitolPharmatose 100 M (10 : 10) and acetonewater (80 : 20)		Aerolizer and 92		[50]

SS: salbutamol sulphate; ASC: antisolvent crystallization; CC: cooling crystallization; and FPF: fine particle fraction.