Review Article
Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
Table 7
Microcomposites carrier loaded DPI formulations.
| Drug | Method | Key ingredients | PSD (μm) | Device and flow rate (l/min) | % FPF | References |
| Rifampicin | Four-fluid nozzle SD | PLGA and CM | 4.50 | Jethaler and 28.3 | ~35–40 | [58] | Ciprofloxacin HCL | co-SD | CM | | Cyclohaler and 60 | | [59] | Meloxicam | co-SD | CM, PVA, and leucine | 5.81 | RS01® and 60 | | [60] | Theophylline | Wet bead milling followed by SD | CM | | Cyclohaler and 60 | | [61] |
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SD: spray drying; co-SD: co-spray drying; CM: commercial mannitol; PVA: polyvinyl alcohol; PLGA: poly(lactic-co-glycolic acid); and FPF: fine particle fraction.
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