Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections

Figure 1

Scanning electron micrographs of SID-treated v. VASE-treated rods, cross sections. Scale bar at bottom right shows 907x magnification and 10 length. (a) PCL alone, treated by the SID method. (b) PCL alone, treated by the VASE method. (c) 30:70 w:w ACV:PCL rod created by SID method; note black circles around large ACV crystals. (d) 30:70 w:w ACV:PCL rod created by VASE method; note absence of large ACV crystals.

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