Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections

Figure 8

Drug release in vitro by VASE- and SID-created devices during infection of Vero cells with HSV-1. Experimental setup matched that of Figure 5. Thirty hours after infection, cell media was removed and ACV concentration was quantified by HPLC using an Agilent 1200 HPLC. Data shown are means ± standard deviation for triplicate wells.