Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections

<table class="fixed-width table-group" id="tab1"><tr><td><table class="table"><colgroup><col style="width:2.91em"/><col style="width:5.19em"/><col style="width:6.02em"/><col style="width:6.79em"/></colgroup><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left"></td><td class="align_center">untr. PCL</td><td class="align_center">SID-tr. PCL</td><td class="align_center">VASE-tr. PCL</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left"><span style="width: 17.3119ptpx;"><svg height="11.5695pt" id="M36" style="vertical-align:-3.18152pt" version="1.1" viewbox="-0.0498162 -8.38798 17.3119 11.5695" width="17.3119pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M861 0V28C774 35 771 41 768 147L759 509C756 612 762 614 851 622V650H681L449 149L221 650H57V622C148 613 153 609 144 479L130 271C123 166 117 123 111 88C104 46 85 34 26 28V0H259V28C192 35 169 42 167 90C166 130 166 173 170 256L185 541H187L411 7H431L675 555H679L683 147C683 41 680 35 598 28V0H861Z" id="g121-75"></path></g><g transform="matrix(.0091,0,0,-0.0091,11.583,3.132)"><path d="M532 0V30C473 38 467 38 467 107V298C467 395 416 451 336 451C307 451 279 439 251 420C226 404 205 389 185 374V453C142 434 94 422 43 413V386C98 378 104 373 104 309V107C104 41 100 38 31 30V0H251V30C191 35 185 40 185 107V337C216 364 255 389 295 389C360 389 386 347 386 276V110C386 44 380 35 321 30V0H532Z" id="g58-108"></path></g></svg></span></td><td class="align_center">18294</td><td class="align_center">17264</td><td class="align_center">17105</td></tr><tr><td class="align_left"><span style="width: 18.6911ptpx;"><svg height="11.6836pt" id="M37" style="vertical-align:-3.29562pt" version="1.1" viewbox="-0.0498162 -8.38798 18.6911 11.6836" width="18.6911pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M861 0V28C774 35 771 41 768 147L759 509C756 612 762 614 851 622V650H681L449 149L221 650H57V622C148 613 153 609 144 479L130 271C123 166 117 123 111 88C104 46 85 34 26 28V0H259V28C192 35 169 42 167 90C166 130 166 173 170 256L185 541H187L411 7H431L675 555H679L683 147C683 41 680 35 598 28V0H861Z" id="g121-75"></path></g><g transform="matrix(.0091,0,0,-0.0091,11.583,3.132)"><path d="M708 439H523V409C587 401 594 395 581 344C562 272 534 184 513 118H511C468 225 428 330 391 434H361C318 317 283 217 244 121H242C218 196 193 273 170 349C157 394 160 401 220 409V439H10V409C60 403 67 394 86 343C127 224 165 109 201 -10H233C273 101 314 199 353 299C393 195 432 99 475 -10H507C554 126 596 251 627 334C648 390 657 401 708 409V439Z" id="g58-117"></path></g></svg></span></td><td class="align_center">25656</td><td class="align_center">25147</td><td class="align_center">23772</td></tr><tr><td class="align_left">PDI</td><td class="align_center">1.402412</td><td class="align_center">1.45663</td><td class="align_center">1.389758</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>untr. PCL: untreated PCL.<br/>SID-tr. PCL: PCL treated by SID method.<br/>VASE-tr. PCL: PCL treated by VASE method.<br/><span class="nowrap"><svg height="8.43779pt" id="M38" style="vertical-align:-0.04980946pt" version="1.1" viewbox="-0.0498162 -8.38798 18.7724 8.43779" width="18.7724pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M861 0V28C774 35 771 41 768 147L759 509C756 612 762 614 851 622V650H681L449 149L221 650H57V622C148 613 153 609 144 479L130 271C123 166 117 123 111 88C104 46 85 34 26 28V0H259V28C192 35 169 42 167 90C166 130 166 173 170 256L185 541H187L411 7H431L675 555H679L683 147C683 41 680 35 598 28V0H861Z" id="g121-75"></path></g><g transform="matrix(.013,0,0,-0.013,11.492,0)"><path d="M524 0V26C466 32 460 36 460 104V297C460 393 411 449 331 449C302 449 276 437 248 419C223 402 201 387 181 372V451C137 432 90 420 42 411V388C96 378 102 374 102 310V104C102 38 97 33 29 26V0H246V26C187 32 181 36 181 104V339C211 365 250 390 290 390C357 390 381 345 381 276V109C381 40 374 32 315 26V0H524Z" id="g121-108"></path></g></svg>:</span> number average molecular weight.<br/><span class="nowrap"><svg height="8.63352pt" id="M39" style="vertical-align:-0.2455397pt" version="1.1" viewbox="-0.0498162 -8.38798 20.3904 8.63352" width="20.3904pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M861 0V28C774 35 771 41 768 147L759 509C756 612 762 614 851 622V650H681L449 149L221 650H57V622C148 613 153 609 144 479L130 271C123 166 117 123 111 88C104 46 85 34 26 28V0H259V28C192 35 169 42 167 90C166 130 166 173 170 256L185 541H187L411 7H431L675 555H679L683 147C683 41 680 35 598 28V0H861Z" id="g121-75"></path></g><g transform="matrix(.013,0,0,-0.013,11.166,0)"><path d="M696 437H516V411C580 402 587 397 574 345C555 271 527 183 505 114H503C461 222 420 328 383 432H357C315 316 278 214 241 118H239C214 195 189 274 165 350C151 396 156 402 216 411V437H9V411C57 405 65 398 83 346C125 226 162 108 199 -11H227C267 100 308 199 346 300C387 195 428 97 468 -11H497C542 124 587 257 617 337C637 392 646 404 696 411V437Z" id="g121-117"></path></g></svg>:</span> weight average molecular weight.<br/>PDI: polydispersity.<br/></div></td></tr></table>

<div>GPC comparison of untreated PCL v. treated PCL.</div>

Journal of Drug Delivery

tab1

Table 1

Table 1: Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections 

Table 1 | Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections 