Rate of Drug Coating Dissolution Determines In-Tissue Drug Retention and Durability of Biological Efficacy

<div>Movat pentachrome stain of arterial sections 90 days posttreatment with Lutonix DCB (polysorbate/sorbitol/paclitaxel formulation; (a)) or IN.PACT DCB (urea/paclitaxel formulation; (b)). Areas of green staining indicate zones of SMC loss and proteoglycan deposition associated with local drug activity. Bar indicates 700 <i>μ</i>m.</div>

Journal of Drug Delivery

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Figure 4

Figure 4: Rate of Drug Coating Dissolution Determines In-Tissue Drug Retention and Durability of Biological Efficacy 