DNA Polymerase: Structural Homology, Conformational Dynamics, and the Effects of Carcinogenic DNA Adducts

Figure 6

Structural overview of the TLS yeast polymerase eta (PDB# 1JIH, molecule A) [41]. 𝛾Pol𝜂 contains stubby fingers (green), and thumb (blue) domains, a palm (yellow) domain, as well as a polymerase associated domain (PAD) (brown). The open nature of the active site allows two nucleotides to be accommodated during synthesis, as well as bulky carcinogenic adducts and DNA distorting lesions.