Translesion Synthesis Polymerases in the Prevention and Promotion of Carcinogenesis
Figure 3
UV light-induced skin cancer in mice. Mice were shaved once per week and irradiated three times per week with for 20 weeks or until the first skin tumor arose. Mice were inspected weekly for the development of skin tumors. All 12 homozygous Polh knockout mice (open diamonds) developed skin tumors by 18 weeks, while all 12 mice (open circles) developed skin tumors by 13 weeks. This Poli-dependent decrease in tumor latency is highly significant (). No difference was found in the histological analysis of skin tumors among the groups. Reproduced with permission from Dumstorf et al. [60].
