Genotoxic Effects of Etoposide, Bleomycin, and Ethyl Methanesulfonate on Cultured CHO Cells: Analysis by GC-MS/MS and Comet Assay

Table 2

Statistical analysis of GC-MS/MS data (base lesions/10⁶ DNA bases).

	Control	0.5 μg/mL	1.0 μg/mL	2.0 μg/mL
Bleomycin-FapyGua
Mean (lesions/10^6 bases)	0.8275	1.348	1.220	2.023
Stand. Dev.,	0.1289	0.3316	0.2299	0.4723
Stnd. error of mean	0.06447	0.1658	0.1150	0.2362
value (vs. control)		0.0133	0.0124	0.0014
Bleomycin-8-OH-Gua
Mean (lesions/10^6 bases)	0.9925	1.123	1.348	1.388
Stnd. Dev.,	0.1658	0.2103	0.3432	0.4115
Stnd. error of mean	0.0829	0.1051	0.1716	0.2058
value (vs. control)		0.1846	0.0559	0.0626
Bleomycin-5-OH-MeUra
Mean (lesions/10^6 bases)	0.5875	0.7400	0.8875	1.275
Stnd. Dev.,	0.3567	0.02944	0.2971	0.3937
Stnd. error of mean	0.1783	0.01472	0.1486	0.1968
value (vs. control)		0.2134	0.1219	0.0207

Statistical calculations are based on four sets of GC-MS/MS measurements using aliquots of the same sets of treated samples.