Recurrence Quantification Analysis of Spontaneous Electrophysiological Activity during Development: Characterization of In Vitro Neuronal Networks Cultured on Multi Electrode Array Chips

Figure 1

An in vitro neuronal network coupled to a multielectrode array chip and the typical recordable electrophysiological activity. The NN is randomly self-reassembled from cryo preserved cortical neurons of mouse. The microelectrode is 30 𝜇m in diameter and the interelectrode distance is 200 𝜇m. After few days of in vitro culture it is possible to record both spikes and packages of spike (bursts).