Biological and medical endeavors are beginning to realize the benefits of artificial intelligence and machine learning. However, classification, prediction, and diagnostic (CPD) errors can cause significant losses, even loss of life. Hence, end users are best served when they have performance information relevant to their needs, this paper’s focus. Relative class size (rCS) is commonly recognized as a confounding factor in CPD evaluation. Unfortunately, rCS-invariant measures are not easily mapped to end user conditions. We determine a cause of rCS invariance, joint probability table (JPT) normalization. JPT normalization means that more end user efficacious measures can be used without sacrificing invariance. An important revelation is that without data normalization, the Matthews correlation coefficient (MCC) and information coefficient (IC) are not relative class size invariants; this is a potential source of confusion, as we found not all reports using MCC or IC normalize their data. We derive MCC rCS-invariant expression. JPT normalization can be extended to allow JPT rCS to be set to any desired value (JPT tuning). This makes sensitivity analysis feasible, a benefit to both applied researchers and practitioners (end users). We apply our findings to two published CPD studies to illustrate how end users benefit.

1. Introduction

Biological compounds and systems can be complex, making them difficult to analyze and challenging to understand. This has slowed applying biological and medical advances in the field. Recently, artificial intelligence and machine learning, being particularly effective classification, prediction and diagnostic (CPD) tools, have sped applied research and product development. CPD can be described as the act of comparing observations to models, then deciding whether or not the observations fit the model. Based on some predetermined criterion or criteria, a decision is made regarding class membership ( or ). In many domains, class affiliation is not the end result, rather it is used to determine subsequent activities. Examples include medical diagnoses, bioinformatics, intrusion detection, information retrieval, and patent classification. The list is virtually endless. Incorrect CPD output can lead to frustration, financial loss, and even death; correct CPD output is important. Hence, a number of CPD algorithms have been developed and the field continues to be active.

Characterizing CPD effectiveness, then, is necessary. For example, CPD tool developers need to know how their particular modification affects CPD performance, and practitioners want to make informed choices between CPD options before deploying a tool in the field.1 Jamain and Hand, summarizing their results in a classifier meta-analysis, comment:

The real question a user generally wants to answer is “which classification methods [are] best for me to use on my problem with my data …” [1].

This question has not been addressed in studies we have read. Indeed, Jamain and Hand generalize the sentiment of R.P.W Duin’s comment regarding comparing automated, heavily parametrized classifiers.

It is difficult to compare these types of classifiers in a fair and objective way [2].

Seemingly, the research community has viewed the end user’s need as too complex to address. Thus, for the most part, researchers have focused on addressing their own needs. End user issues, when discussed, have been constrained to specific problem domains. It might be fair to state that each end user’s need is, in some way, unique. However, that does not mean that the apparent complexities faced by end users cannot be identified and managed. Ideally, a means of satisfying end user needs without sacrificing researcher needs will emerge. At a minimum, it should be possible for end users to be enlightened regarding measure suitability (which measures best quantify how a CPD will impact their situation). This paper is a first step in identifying a general structure of CPD problems2 faced by end users and using that structure to identify CPD evaluation measures and tools relevant to end users. To the extent that research studies present CPD performance information by which end users can estimate impact in their situation, the studies provide improved service to the end user.

Our primary focus is on summary statistics. In the current context, summary statistics are formulae that take measurement suite elements as input3 and output a single value which represents the target CPD’s overall quality. However, because multiple values are condensed into a single value, information is lost. To the extent essential information is retained, the summary statistic can prove useful for CPD evaluation. A key characteristic of summary statistics is that they are not monotonic; they have optima. Useful summary statistic optima indicate overall classifier quality. Ideally, these summary statistics also quantify some aspect of classifier output efficacious to end users. End users can directly use such values to estimate how the CPD will impact their situation.

As presented by Hand [3], measurement theory distinguishes between two entity attribute types: intrinsic, those that are part of an entity’s definition (e.g., density or mass) and extrinsic, those that are expressions of the entity’s interaction with the environment (e.g., weight). Attributes such as density and weight can be quantified, so we can also talk about intrinsic and extrinsic measures. When reported in joint probability tables (JPTs), CPD output is partitioned into four distinct categories: , , , and . After any dataset has been tested, the final object count in each category is influenced by the environmental factors rCS and boundary (). (rCS is the relative sizes of the classes in the test set . is an element vector that defines a “surface” that encloses one class, for example, “class .” In every case, there will also be an optimum boundary4 (). All elements outside that surface are in class “”, rather than class “.” Because , , , and are sensitive to rCS and , they are extrinsic measures.

1.1. Nomenclature

Although this paper applies well-established stochastic concepts, not all discussions use the same terminology. To avoid confusion, we define our lexicon for quantities measured (each being the size of the defined set):: correctly identified events in class , the “class of interest” (if such a class exists);: correctly identified events of class , the other class;: class events incorrectly flagged as class ;: class events incorrectly flagged as class ;: events flagged as class ;: events flagged as class ;: actual class events in the data set;: actual class events in the data set;: the data set;These values are often presented in an JPT as in Table 1. When appropriate, these symbols will also be used to represent populations. Context will determine whether a quantity or a population is being referenced.

End users are interested in how a process will function in their environment, so they need measures sensitive to extrinsic factors. From a purely academic perspective, the goal for many researchers is to characterize the CPD process independent of extrinsic factors; thus, they want intrinsic measures. Presumably because of the immediacy of the need, significant progress has been made in identifying and characterizing intrinsic measures.5 We are interested in extrinsic measures useful for end users; little attention has been paid to their needs.

Because of the disparity between researcher and end user needs, providing for end user needs requires careful consideration. A researcher is interested solely in CPD performance; effects caused by external factors must be accounted for, if not eliminated. In contrast, end users need to incorporate external factors, not compensate for or eliminate them. Thus, in order to have research reports that are readily applicable by end users may require providing values that hold little relevance for researchers. We propose an “end user efficacious” measure suite and a means by which end users can tailor research results to their specific environment.

This study builds on Sokolova et al. and other CPD summary statistic characterization studies [414]. A challenge categorical problem evaluators face, when comparing to CPD results reported by others, is adjusting for data set effects. One of the major data set issues is that test sets used may well have different rCSs, with different applicability and/or utility. This can cloud results. As an example, we ran a CPD on two test sets drawn from the same class populations. Since both the class source populations and CPD were the same for each test, one would expect statistically indistinguishable output. However, since JPT categories are extrinsic, the anticipated similarity may be masked. The only difference between the test outputs shown in Table 2 is one test set has a relative class size of 9 : 1 () and the other a relative class size of 1 : 1 (). The CPD performs equally well in each test; however, rCS introduces a bias in the JPTs that makes the CPD performance equality difficult to recognize. When , there are twice as many observations as . However, when , the ratio between and goes to 18 : 1! Without knowledge of the test sets used, an observer could well conclude that these were two significantly different CPDs, with significantly different applicability and/or efficacy. This is an obvious problem for researchers, thus significant effort has been applied to mitigate it; a selection of rCS invariant measures are available: (i)the Youden index [15]; (ii)two related measures, diagnostic odds ratio (DOR) [16] and diagnostic power (DP) [17] (; (iii)the Matthews correlation coefficient (MCC) [18]; (iv)the receiver (or relative) operating characteristic6 area under the curve (AUC) [19, 20];(v)information theoretic measures such as the information coefficient (IC) [21, 22].

Youden was addressing the rCS’s biasing effect in 1950; thus, the problem has been known for well over half a century, yet reports regarding mitigation are still entering the literature [9, 23]. In the works reviewed, consideration of end user problem environment was tightly constrained and the view of the data virtually unrestricted. We invert these criteria; first identifying problem interactions with rCS (a broad view of end user needs), then viewing the data such that it addresses the question posed by Jamain and Hand (a constrained view of the data).

rCS is generally confounding in the research environment; this is presumably also true for some end users. However, for other end users, rCS may be important for their problem. For these end users, basing decisions on rCS invariant measures may be misleading. Hence, we start by asking two questions: (i)“Is rCS important for all end user CPD problem domains?” (ii)“If not, what characteristics define when to incorporate rCS?” Consider relating these two questions to a pair of real-world problems. A less effective CPD used with a rheumatoid arthritis test could lead to either more people than necessary being treated, or fewer. Likewise, a poorly selected intrusion detection boundary could cause an IT system to have excessive errors (false alarms or missed attacks).

In order to consider the two questions posed above, we will use a statistical nomenclature to describe a supervised CPD test bed. Viewed from a statistical perspective, observations on the dataset processed provide estimates of the underlying (class) population probabilities (rCS is the odds expression of that probability). Observations in the test system input are drawn from the specific populations (because the source class populations are known for each observation, a “ground truth” exists). The source population relative class sizes can be represented as a probability, for example, the probability that a randomly selected input will be a member of class . This is the leading probability (), the probability before the inputs interact with the defined process.7 In the examples stated, class members would consist of RA-positive individuals and malicious information system activity. In the field, “ground truth” for any particular individual cannot be known prior to being processed (otherwise there would be no need for evaluation). However, in the test scenario being described, ground truth is known for each test set member. Since the source class is known for each CPD input element, input uncertainty does not affect any individual CPD output.

The balance of this paper is organized as follows. Section 2 considers relative class size. Section 3 describes the research protocol used in this study. Section 4 discusses efficacious measures for end users and considers existing summary statistics. Section 5 considers a cause of rCS invariance in measures and implications thereof. This is followed in Section 6 where we present two examples using the proposed format and tool. The main body of this paper closes with a summary of our findings and presents future work in Section 7. Four appendices with equation derivations and additional JPT normalization details wrap up the paper.

2. Relative Class Size

Abstractly described, test set elements interact with the defined process. This interaction “modifies” the elements (perhaps only by adding a tag indicating strength of the match with a model), leading to a test for class membership. The probability that a randomly selected output will be detected as a member of class is the subsequent probability (). describes the state of the data stream after interacting with the defined process and is the combined result of the input mix (quantified as a probability () or an odds ratio ()) and the defined process. The defined process contributes its own uncertainty () to the observed output. Thus, the test system can be described by the equation . The CDP test set model is illustrated in Figure 1.

Tying the test set model to the examples, consists of the patient’s RA diagnosis and the stream of intrusion detector classifications. for the RA diagnosis consists of the strength of the match between the compound assayed and RA, test quality and the boundary used to determine class membership (diseased, not diseased). Similarly, for the intrusion detection example consists of the appropriateness of the model that represents the malicious activity, the reliability of tags defining the activity, and the algorithm (or perhaps rule set) used to make malicious/non malicious determination.

In the CPD test system described, is a characteristic of the input test dataset; hence, it is always fixed.8,9 It is, in fact, related to rCS: We can now restate the original question within our framework: “are there problem domains where is important rather than confounding?”

One such situation could arise where individual results are significant only to the extent to which they contribute to a cumulative result. Consider setting intrusion detection boundaries. The end user is interested in limiting the impact of intrusions and intrusion prevention. The impact is cumulative, with each evaluation activity contributing. In this case, relative class size (expressed as or ) is important. If the end user were to base its boundary on by using a rCS invariant measure (a measure that could not reflect the end user’s estimate of their attack rate), there would likely be either excessive false alarm processing costs or excessive expenses due to missed attacks. Cases of this type, where each individual outcome contributes to a cumulative result, require knowledge of both and .

Are there conditions in which , rather than being essential, might instead cause errors? We suggest that one such situation is when individual results are important and cumulative results are not. Consider a person tested for rheumatoid arthritis (RA). Depending upon the physician’s office ordering the test, the frequency of s tested could vary considerably.8 If each office set test boundaries to minimize their respective error rates, there would be a range of test scores that would be classified differently by different offices. Clearly, both diagnoses cannot be correct; a person cannot be simultaneously and . In this case, considering the physician’s rCS-based does not minimize the error for the patient.

With regard to rCS, we see that while basic research benefits from rCS invariant measures, these measures are not suitable for all end users; rCS invariance will be confounding for some end users. For these end users, any specific environment can have any of (literally) an infinite number of rCS values. Indeed, an end user’s expected rCS can vary over time. Thus, a “one size fits all” solution will not be particularly efficacious. Our goal to provide for end user rCS needs, thus, resolves into two tasks: (i)identify both rCS-sensitive and rCS-invariant measures that are efficacious for end users;(ii)identify a means by which end users can tailor reported CPD results to reflect performance for their expected rCS.

3. Research Protocol

Although in many problem domains, populations tend to be normally distributed, this is not universal. In order to avoid limiting the applicability of our results, we use analytic procedures that are insensitive to distribution. To preserve generality, our analysis is strictly nonparametric; medians are used instead of means and quantiles are used instead of standard deviations. We also execute our tests with the Monte Carlo method, a nonparametric analytical tool often used when problem complexity (in our case, potential end user problem complexity) is not amenable to mathematical analysis.

CPD evaluation studies can be partitioned into two groups: those that use “real-world” data and those that use simulated data. Characterizing CPD evaluation measures requires observing how the measures respond as CPD output varies. Real-world data, such as those available in repositories, for example, the UCI Machine Learning Repository, provide the opportunity to test against a wide variety of complex data types [24]. However, observing the effect of incremental changes on real-world data is difficult at best. For our purpose, we use simulated CPD output. Although any distribution could be used, we assert normality when generating datasets. All data sets used in this study were generated such that the classes were normally distributed (; is the distribution mean and is the standard deviation). The figures displayed were based on four hundred datasets consisting of two hundred thousand randomly drawn observations from two source populations: positive = and negative = . Separate tests were run with datasets having rCSs of A total of 5,600 independent data sets were used in this study.

For each summary statistic evaluated, we observed how the reported metric was affected by rCS versus boundary versus metric output. The 3D results are presented as contour plots. Because the measure values are asymptotic to one (thus nonlinear), we use the median of the four hundred runs for each test case; means are not valid for non-linear scales. It is impractical to present confidence intervals on 3D data, but on the 2D graphs in Appendix D, the ninety percent confidence interval (90% CI) is displayed for select test series. To illustrate, the 90% CI is indicated by the vertical lines at each rCS tested in Figure 2; the horizontal line indicates the median.

This protocol provides the flexibility and repeatability necessary for analysis, yet abides by the constraints necessary for analysis of less tractable problem domains with difficult problem environments (e.g., complex CPD input and output distributions).

4. End User Efficacy

End users have two activities: CPD selection and CPD application. Regardless of any end user problem distinctions, these two activities address common interests: (i) process application is concerned with the accuracy of the CPD for both possible outcomes: (1)“given that the test is positive, to what extent can the result be relied upon?” (2)“given that the test is negative, to what extent can the result be relied upon?” Mathematically, this can be expressed as a conditional probability, or a conditional odds. These values are monotonic, so difficult to use for optimum boundary identification; (ii)  process selection needs to choose the CPD with the best expected accuracy (“given the set of choices for CPD, which CPD will provide the best results and to what extent can its results be relied upon?”). Summary statistic output (based on the two monotonic measures) can inform end users for process selection. The end user efficacious measures differ for the two rCS problem types; so they are further discussed in the following sections.

4.1. When rCS Is Important

Measure efficacy depends upon whether or not the impact on the end user is cumulative. The two CPD application questions can be expressed mathematically as (i)“given that the test is positive, to what extent can the result be relied upon?” ; (ii)“given that the test is negative, to what extent can the result be relied upon?” .Proportions, being asymptotic to one, are not ratio measures [25] and, thus, have limited utility. We use odds ratios instead.

The effect is cumulative (or additive); so the two conditional expressions, instead of being a measure suite, provide ancillary information. For CPD selection, end users will be interested in the proportion of the input stream that can be expected to be correct. Thus, a measure such as the total accuracy rate (TAR) represents the per element expected accuracy. TAR, being asymptotic to one, is not a ratio measure; therefore, averaging is not a valid operation. The total accuracy odds ratio (TOR) would be a better choice:

Proportions, such as TAR and odds ratios such as TOR, are alternate expressions of the same CPD output. In fact, odds ratios can be transformed into proportions using (1).

Figure 3 shows TAR, as boundary and rCS vary. The TAR contour appears to vary little and be relatively constant over a wide boundary range. The optimum boundary (shown on the graph as the black dashed line) intersects the -axis at around 1.45 and slopes toward 1.0. Additionally, the contour around the optimum boundary flattens as rCS increases. We can also see the optimum boundary and the reported accuracy rate both change as rCS varies. TAR is sensitive to rCS; thus, it is useful for problem domains where cumulative effects are important.

There are two other commonly seen rCS-sensitive summary statistics: F-score and Matthews correlation coefficient9 (MCC). Another measure, information coefficient (IC); is becoming more prevalent, so we consider it as well.10

4.1.1. F-Score

F-score is the complement of a summary statistic proposed by van Rijsbergen [26]. The measure suite for F-score is recall and precision; van Rijsbergen’s measure is based on information retrieval performance criteria put forth by Cleverdon [27]. Cleverdon’s criteria address practitioner needs in information retrieval. Recall quantifies a CPD’s completeness (the probability that the desired observations in the database are correctly identified). Precision quantifies the probability that undesired observations are mistakenly labeled as desired. For the information retrieval domain, these data11 seem to be what end users need to know (F-score is now being seen in other problem domains.)

Recall and precision correspond to the conditional probabilities and (also known as “True positive rate” (TPR) and “positive predictive value” (PPV)). In the problem domain within which they were introduced (information retrieval), these measures quantify how well an CPD relates an object to a concept, such as selecting a document based on keywords. F-score is defined as where is the relative weight of precision and recall: If precision and recall have equal weights, then , which is the harmonic mean of precision and recall: Since precision and recall are conditional probabilities, we can convert the F-score equation into JPT values. After substitution and rearranging terms, The derivation is provided in Appendix A. Notably, using the harmonic mean results in , and not being equally weighted in the denominator. While this may be suitable for the information retrieval domain and some others, it is hardly universal.

In contrast to TAR, F-score’s rCS sensitivity varies, depending upon the class monitored. The effect can be seen in Figures 4(a) and 4(b). Interestingly, both TAR and F-score are well-accepted measures. This may indicate the existence of another CPD problem structure element. Analysis of this possibility is postponed for later consideration.

4.1.2. Matthews Correlation Coefficient

The Matthews correlation coefficient (MCC) is a more recent measure, introduced by Matthews [18]. MCC is the application of Pearsons correlation coefficient to CPD evaluation. In a subsequent classifier measure survey, Baldi et al. restated the measure in the form commonly seen today [21]: Although not mentioned explicitly in Matthews’ work, Baldi et al. note that the equation requires normalized distributions: is the class of the input dataset and . is the mean of . is treated in the same manner. One effect of distribution normalization is class size equalization: (this is discussed in Section 5). The expressions used to generate normalized JPTs are shown in Table 3 the class size equalization is indicated by the ones in the “normalized totals” row. To demonstrate Matthews initial intent to use normalized distributions, we recalculated Matthews et al.’s original results using both actual and normalized JPTs. The values using normalized JPTs matched Matthews results; the values using actual JPT values varied from Matthews reported values by approximately a factor of twenty. Thus, MCC, when introduced, was intended to be calculated on normalized JPTs.

The JPT normalization prerequisite applied by Matthews et al. and noted by Baldi et al. seems to have been lost, although the belief that MCC is rCS-invariant persists [2834].12 As a consequence, Baldi et al.’s equation is sometimes applied without first normalizing the JPTs. In two of these reports, Cannon et al. [28] and Mirceva et al. [34] include JPTs. Upon recalculating their results, we determined that the values presented were based on nonnormalized JPTs. In both cases, there were substantial differences between the results on normalized and nonnormalized JPTs. In the Cannon et al. results, the difference affected not only the values, but also the process rankings. Using normalized JPTs, MOLPRINT, the process ranked last, moved into the upper fifty percent of processes tested. Having rankings of processes substantially change due to such changes could result in selection of a suboptimal process for use in real-world settings.

Figure 5 shows how normalization impacts the rCS sensitivity for MCC. Figure 5(a) shows MCC’s response when the raw JPT values are used. The peak boundary (indicated on the graph by the dashed line) shifts as rCS varies and the value decreases as rCS increases (indicated by the sloping dashed line that intersects the contours). In contrast, Figure 5(b) shows that with JPT normalization, the peak boundary and calculated optimum MCC value are fixed (indicated by a vertical dashed line and contours that do not intersect the peak boundary). Exactly the same data sets were used for both graphs; the only difference is the presence or absence of JPT normalization.

Comparing MCC results is complicated by the fact that the published reports we surveyed did not identify whether or not the MCC values reported were on normalized JPTs or not. As seen in Figures 5(a) and 5(b), comparing results across tests where rCS is not normalized could lead to errors. Since rCS affects the optimum boundary when raw JPTs are used, a simple correction of reported values by recalculating MCC on normalized JPTs will most probably be for a suboptimal boundary; thus, the corrected MCC value will also be suboptimal.13 In this section, we characterized MCC using nonnormalized data. Appendix C derives an rCS-invariant MCC expression.

Relative to end user interests, it is unclear what MCC quantifies and under what context the value will be relevant; MCC’s end user efficacy is limited to optimum boundary identification.

MCC’s complexity makes determining an underlying measure suite difficult. This detail will be addressed in the future.

4.1.3. Mutual Information Coefficient

Rost and Sander introduced an information-theory-based measure into the literature in 1993 [22]. It was subsequently included in a measure comparison by Baldi et al. [21]. Since then, it has gained some traction in biological literature [3543] and has been seen in network management literature [44]. The measure is sometimes called the information coefficient or mutual information coefficient; we use the acronym IC.

As explained by Baldi et al., IC is the mutual information () normalized by the entropy in ground truth (); is the mutual information contained in ground truth regarding the test set and the CPD prediction of ground truth, as contained in : Expressing and in terms of JPT categories, where

Information-theory-based measures are gaining traction in the literature [3543]. Some of these reports indicate the belief that the measures are rCS-invariant [38, 40, 43]. Solis and Rackovsky [41] note that their particular information theoretic measure may not be rCS-invariant. The belief that information theoretic measures are rCS-invariant comes from the fact that information theory applies to probability density functions, which are always normalized () [45, 46]. Unless JPTs are normalized prior to use, IC and related measures cannot be guaranteed to be rCS-invariant.

Like other measures, IC compares target CPD output to an CPD using random classification. However, it differs in that IC is based on the entropy existing in the test set and CDP output. If the input and output are the same, then ; if the output of the process is equivalent to that of random selection, then . A side effect of IC’s use of logs is increased computational complexity. All of the other measures evaluated have a complexity of , IC is . This may limit IC’s utility for large data sets. IC’s computational complexity did affect our analysis. Had we calculated IC on the two hundred thousand element test sets used for the other measures, it would have taken approximately six months. Consequently, we tested IC on twenty thousand element test sets. In Figure 6, we can see that the peak boundary shifts as rCS increases; thus, IC is not rCS-invariant. As with the other rCS-sensitive measures, JPT normalization can confer rCS invariance.

4.2. Findings regarding rCS Sensitive Problems

(i)Of the four rCS-sensitive summary statistics reviewed, TAR and F-score appear to be efficacious. (ii)Because the reaction to rCS of TAR and  F-score are opposite, this may indicate the existence of other elements in the CPD problem structure (we will address that in future work.) (iii)MCC and IC, regardless of their apparent utility for researchers, do not seem to quantify information directly usable by end users. This section has not covered how end users can take a single reported value and convert it into one applicable to their specific rCS environment. This will be discussed in Section 5.

4.3. When rCS Is Confounding

When rCS is confounding, in addition to quantifying end user issues, efficacious measures must be rCS-invariant. The following discussion will apply normalized JPT input when necessary.

The CPD application expressions for this problem type are normalized versions of those for rCS-sensitive problems.

“Given that the test is positive, to what extent can the result be relied upon?” Mathematically, this can be expressed as a conditional probability, or a conditional odds on normalized JPTs. For the reason mentioned in Section 4, we use the odds, normalized .

“Given that the test is negative, to what extent can the result be relied upon?” The odds expression for this is normalized .

Test selection needs to choose the CPD with the best expected accuracy (“given that a result will be rendered, to what extent can the result be relied upon?”). The two CPD application questions provide operational information, but are also the basis for this noncumulative CPD problem selection decision. As such, they can be considered the measurement suite for the CPD selection decision. The CPD selection decision requires an end user efficacious summary statistic. The expected prediction accuracy (EPA) is the average of the two odds ratios identified in the previous paragraph. Each CPD event is independent and the conditional values are normalized. The special conditions that dictate applying either the geometrical mean (a compounding effect) or the harmonic mean (unequal set sizes) do not exist; so the arithmetic mean of the conditional odds on normalized JPTs is appropriate: To our knowledge, this end user summary statistic is not found in the literature. We apply this summary statistic in the meta-analysis in Section 6.

As noted in the introduction, rCS-invariant summary statistics are already in use. We review three commonly seen rCS-invariant summary statistics: (i)the Youden index [15]; (ii)two related measures: diagnostic odds ratio (DOR) [16] and diagnostic power (DP) [17] (); (iii)the receiver (or relative) operating characteristic area under the curve (AUC) [19, 20]. Two other summary statistics, the Matthews correlation coefficient (MCC) [18] and mutual information coefficient (IC) [21] are commonly held to be rCS-invariant, but in fact are not. They were discussed in Section 4.1.

4.3.1. Youden Index

The Youden index (traditionally represented by ) was proposed in 1950 and is seen in medical diagnostic studies [15]. There are a number of expressions of . The original is Perhaps a more common representation is where Further, sensitivity is also known as the true positive rate (TPR) and specificity is the complement of the false positive rate; specificity = . Hence, an even simpler (thus better, according to the minimum description length principal) definition would be In this form, the Youden index can be taken to be a summary statistic of the measure suite .

is special in that indicates an CPD with an output equal to that of tossing a fair coin. with a perfect CPD and for an CPD that misclassifies everything. As noted in their respective literature bases, shares a characteristic with AUC, in that it is insensitive to rCS. On our source populations, the optimum boundary is approximately 1.4. This can be seen in Figure 7. There is an issue with end user efficacy, however. quantifies the spread between the TPR and FPR. This information has little bearing on the “pretest” question posed at the beginning of this section.

4.3.2. Diagnostic Odds Ratio (DOR) and Discriminant Power (DP)

Two related measures are the diagnostic odds ratio (DOR) [16] and discriminant power (DP) [17]. DOR is defined as where is true positive odds (TPO) and is false positive odds (FPO). After simplification, Discriminant power is defined as where Recasting the equation, we get The derivation is provided in Appendix B. Comparing the two measures, we see that

and are found in medical research. Interestingly, and when either or , both need not equal zero. Similarly, and when either or , both need not equal zero. Hence, an CPD can classify some observations correctly (total Accuracy > 0), yet have and . This is counterintuitive, since one would expect and to indicate a totally ineffective CPD and and to indicate a perfect CPD, rather than something in between. Since and are (statistically) independent,14 (as are and ), the and could, in a probabilistic sense, be interpreted as the odds that, given two random observations, one will be classified and the other (one will be classified and the other ). While the question seems similar, the fact that the and optimum boundaries are different from the other inherently rCS invariant measures tested suggests that the two questions are significantly different. Perhaps this is because the and treat the problem as a multiplicative function; we identify the problem as an additive function. This value would seem to be directly relevant in niche CPD scenarios, but not to general CPD problem types.

In medical studies, when the event tested for () has a low probability, DOR approximates relative risk: the rate at which the event was observed in group A versus the rate observed in group B. This is valuable information. However, when applied in the more general CPD domain, there is a problem. In any specific CPD task, the category of interest may not have a sufficiently low probability ; thus, the approximation may not always be acceptably close.

Unfortunately, DOR and DP have a challenging sensitivity to boundary; the optimum boundary is indicated by (or ). Thus, for any test run, the boundary with the smallest relative to gives the best accuracy. Not only is this counterintuitive, but also a potential error source. The problem originates from the fact that the greater the (or ), the better the results. Thus, if the boundary used to partition the test output is not at (or ), the results may appear better than they really are.15 Most observations regarding DOR apply to DP as well. For example, when .

One important characteristic of DOR and DP is that they are rCS invariant. An important difference between DOR/DP and the other rCS-invariant measures is that their optimum boundaries, although constant in our tests, are offset from the “minimum error boundary.” These effects can be seen in Figure 8.16 Since DOR and DP are minima, they follow a valley in the contour graph, instead of a ridge, Also contrary to the other measures, DOR decreases when the absolute class size effect becomes noticeable. This means that the contours are closed, instead of open as seen for the other measures. DOR’s vertical optimum boundary line and constant value (seen in Figure 8(b)) indicate that DOR (and hence, DP) is rCS-invariant. Because of this boundary bias, they may not be useful for selecting boundaries. For example, in our test environment, TAR at the common optimum boundary is 0.994, TAR at DOR optimum boundary is 0.958; the difference is significant at the 95% confidence level.

4.3.3. Receiver Operating Characteristic Area under the Curve (AUC)

ROC has a solid history. Swets campaigned diligently to establish it as the evaluation criterion of choice [20, 47, 48]. The measurement suite is the basis for the AUC summary statistic. The title originates from the fact that it is the area under a “ROC curve,” a curve defined by false positive () and true positive () rates. These values are calculated from JPTs of CPD output for a number of boundaries across the observed range, then graphed as the ROC curve [19, 49].17 The literature describes the ROC curve (AUC) as being rCS-invariant as well as boundary-invariant. Because it is boundary-invariant, AUC is a popular tool in our present research environment. However, AUC has been criticized on theoretical terms recently [50, 51].

In contrast to the other summary statistics reviewed, AUC is generally accompanied by the ROC curve (indeed, the ROC curve may be presented without providing AUC). To a person skilled in the art, the ROC curve provides a great deal more information regarding CPD performance than does the single value AUC summary statistic18 (this is, of course, true for any measure suite, since consolidation of multiple values into a single summary statistic value means that information is lost).

Compared to our end user focused criteria, ROC-AUC, being boundary-invariant, is not useful for boundary identification. Nor is it efficacious for end users.

There are numerous ROC-AUC variants [52, 53]. Vanderlooy and Hüllermeier determined in their comparison, that despite intuitive appeal, none of the variants confer any CPD selection improvement. From the end user perspective, since the underlying measure units remain the same, they all have the same limited efficacy.

Figure 9 shows the optimum boundary versus for the proposed normalized PPV, NPV average and existing summary statistics, normalized MCC, Youden index, and DOR. As can be seen in the figure, DOR peaks at a different boundary than the other rCS-invariant measures tested, and (excepting DOR) the optimum boundary is relatively stable until , after which the detected optimum boundary starts dropping rapidly.19 For our context, a key finding from Figure 9 is that not only does DOR have weak end user efficacy, it also should not be used to identify the optimum boundary.

4.4. Findings regarding rCS-Invariant End User Problems

For problems requiring rCS invariance, we find that(i)end users need three values. For CPD selection, the expected total predictive accuracy (a summary statistic) is important. When the CPD is used in the field, the summary statistic value has no meaning. Instead, end users need the information provided by the two measure suite elements; the positive predictive value odds ratio and the negative predictive value odds ratio . (ii)Although many commonly seen summary statistics can be used to identify the optimum boundary, as seen in this study, not all can (e.g., ROC-AUC and DOR). Figure 9 shows how the optimum boundary identified by DOR differs from that identified by the other summary statistics tested. (iii)Of the rCS sensitive summary statistics evaluated, only the EPA output answers the end user’s CPD selection question. The others may be useful for niche problems, but provide little useful information for the “common” end user.

5. JPT Normalization

In statistical circles, standardizing distributions is a well-established technique. One effect of standardization is that the area under the probability density function (pdf) equals 1. This simplifies pdf analysis, since the area of any segment of the area under the curve can be interpreted as the probability of an event occurring within that segment. Similarly, distribution standardization facilitates pdf comparisons. Since the CPD analysis domain considers processes with overlapping pdfs, it intersects with the pdf comparison domain, but is neither a superset nor a subset.20 Where appropriate, distribution standardization is a useful tool.

In CPD analysis, distribution standardization takes the form of JPT normalization. Table 4 shows a JPT displaying “raw” data—actual category cardinality. After normalization, the class totals (bottom row in Table 5) are one. Thus, JPT normalization seems to be a cause for rCS-invariance in measures. As such, it provides a benefit to end users with rCS invariant problems: any JPT-based CPD evaluation measure will have rCS invariant output, if the input JPTs are normalized. (Illustrated in Figure 10).

Although any measure can be rCS-invariant when the JPTs are normalized, some measures have emerged which have intrinsic rCS invariance. These inherently rCS invariant measures all have (ratios that normalize the JPTs) as measure suites, thus rather than being counter examples, they provide empirical evidence that JPT normalization is the root cause for rCS invariance in measures; proof is beyond the scope of this paper. An overview of commonly seen rCS invariant measures is provided in Appendix D.

There is also a benefit for end users with rCS-sensitive problems. Statisticians use distribution standardization to mitigate rCS effects; however, the process is reversible. JPTs with can be “tuned” to any desired rCS simply by multiplying one class by a constant so that equals the desired value.21 Thus, an end user with an rCS-sensitive problem can adjust reported results to fit their need. JPT tuning also allows end users to execute sensitivity analyses and estimate how the CPD will perform in their environment, over the expected rCS range. These insights are applied to a real-world problem in Section 6; a comparison of two RA diagnostic tests and an intrusion detection problem.

However, the optimum boundary is rCS-dependant; thus, the tool is not complete. To apply to all end users, results for all possible optimum boundaries would need to be provided.22 This is impractical, if not impossible, for CPD test reports to include. As illustrated in Endnote 15, the tuned JPTs will indicate trends, but cannot be considered definitive. Nonetheless, JPT tuning extends JPT normalization in a way we have not previously seen in the literature and provides end users with a useful capability.

6. Examples

In this section, we use our proposed end user efficacious data analysis on two real-world problems, a meta-analysis23 comparing two medical diagnostic tests for rheumatoid arthritis (RA) by [54] and data from a cyber security masquerading study by [55].

6.1. A Meta-Analysis of Rheumatoid Arthritis Diagnostic Tests

The meta-analysis is quite thorough and accounts for many potential variations between studies. Three hundred and two relevant studies were found; eighty-six satisfied the rigorous inclusion criteria. The team concludes that one test is better than the other, however, does so without using a summary statistic. Our reanalysis adds the three recommended measures identified in Section 4.3.

The study uses two measures: positive likelihood ratio () and negative likelihood ratio (). Given a typical test using supervised inputs (where ground truth is known), these two values are efficacious for researchers. They are less efficacious where end users have only the CPD output and ground truth is unknown. As we note in Section 4.3, PPV and NPV are more relevant for end users.

On pooled data, the differences between the tests were statistically insignificant. However, the results were statistically significant. On the pooled data, the “anti-CCP”24 positive test results were more frequently correct than the “RF”25 diagnoses. The authors make one important point regarding rheumatoid arthritis treatment; it is harmful and costly to treat persons with false positive results. Hence, it is important to correctly diagnose negatives as well as positives: total expected predictive accuracy (EPA) is important for rheumatoid arthritis treatment. JPT normalization allows measurement of EPA that is rCS-invariant. Using normalized JPT data, In our extension to Nishimura et al.’s report, we calculate the normalized EPA, PPV, and NPV on the pooled test data. Table 6 shows the original likelihood ratios reported by Nishimura et al. and EPA (the parenthesized range is the 95% confidence interval.26) s and PPV show similar values, but is about one-sixth of the NPV; end users should be cautious when interpreting likelihood ratios. Comparing EPAs for each test and keeping in mind the end user context requires rCS invariance, the anti-CCP test correct diagnosis rate is a little more than twice the correct diagnoses rate of the RA test. This is true, even though, as can be seen in Table 7, the RF test actually more accurately detects RA’s presence.

The authors note that “the better accuracy of anti-CCP antibody was mainly due to its higher specificity.” In comparing the JPTs in Table 7, the anti-CCP pooled data summary in Table 7 shows that the anti-CCP test is actually less accurate in detecting diseased individuals—and at a statistically significant level (0.67 for anti-CCP is (statistically) significantly worse than the 0.69 reported for RF). We see that the anti-CCP actually detects RA less reliably than the RF test; the improvement is, in fact, entirely due to better specificity (correctly identifying nondiseased). In a case such as this, where each test is more accurate on one class, rather than one test being more accurate on both classes, it may not always be clear if there is any net diagnostic improvement. Normalized total predictive accuracy quantifies net diagnostic improvement in a way that may help clarify these issues.

This RA example is an rCS confounding type problem; in order to mitigate rCS bias, JPT normalization should be applied. We can now apply JPT tuning to illustrate how rCS can skew results; it is possible to estimate the cumulative test results that GPs and RA specialists will actually observe in their respective practices. The method actually “tunes” the JPTs; any desired rCS can be set.27 A general practitioner may occasionally test for RA. Actual testing rates do not appear to be publicly available; so for computational simplicity, we assume the odds are one to one hundred that someone tested actually has the disease. Because of his/her specialty, a rheumatologist may have a new patient base that is highly skewed toward RA-positive. We assume a one hundred to one ratio. What total accuracy ratios will the two offices observe for the two tests? An JPT tuned to the rheumatologists’ patient base is shown in Table 8, an JPT tuned to the GP’s patient base is shown in Table 9. The EPA odds ratio observed by the rheumatologist would be anti-CCP: 670, RF: 250; the GP would observe total accuracy ratios of anti-CCP: 144, RF: 131, a statistically insignificant difference. Summary Table 10 shows that practices will have radically different experiences with the two tests, although the anti-CCP test is still best for the patient, regardless of the office.

6.2. A Cyber Security Masquerade Study

The cyber security problem domain is one where cumulative effects (e.g., processing false alarms ()) are important. Consider an end user desiring to detect masquerading attacks, in which an attacker pretends to be an authorized user in order to gain access to a system. Determining the appropriate boundary for the detector is necessary in order to balance the effects of false alarms and missed attacks. This balance is subject to the relative volume of normal and masquerade system activity; thus, rCS is important; end users will want to incorporate rCS.

Schonlau et al. simulate a masquerade attack by capturing UNIX commands resulting from specific users, then inserting UNIX commands generated by another user into the original command stream. They compare a number of detection algorithms. The best performing was based on data compression. The Bayesian classifier [55] they used did not perform as well. We compare the two algorithms using the seven summary statistics discussed earlier.

Schonlau et al. use ROC curves to compare their various detection algorithms. From a research perspective, this is appropriate, since ROC is invariant to rCS and does not require boundary selection. However, as noted in Section 4.3.3, ROC provides limited information to end users. To illustrate the effect of using an inappropriate measure type, we reanalyze one of the user command streams with both rCS-sensitive and rCS-invariant measures. Table 11 shows the results.

For all seven summary statistics considered, the classifier with the higher value is better. Clearly, regardless of the measure, the compression algorithm outperforms the Bayesian classifier. The summary statistic values and associated optimum thresholds, however, vary widely.

What do we learn about the two classifiers from the measure values? The IC measures information content; MCC measures covariance. Youden index and DOR/DP quantify more esoteric characteristics. All four measure classifier performance relative to random selection using a fair coin, an issue particularly relevant to researchers, who generally consider a fair coin to be the most ineffective classifier. ROC-AUC, being rCS- and boundary-invariant, also has attractive characteristics for research. End users, however, are concerned about the net result, not distance from random selection. While each of these five measures quantify a characteristic related to the classifier performance characteristic of interest, none can be transformed into a value useful in the intrusion detection domain.

JPT tuning can help end users make more informed decisions. Schonlau et al.’s test sets consisted of one hundred blocks of concatenated UNIX commands. For “user 24,” . “In the wild,” one would expect rCS to be considerably smaller. For this example, we will assume that the end users expect . For the intrusion detection problem domain, TAR or F-score may provide the most information regarding end result. TAR includes both and ; F-score only includes .28 An IT system administrator may be most concerned about intrusion risk and detection overhead, thus not so concerned about . If so, then F-score may be most relevant when comparing cyber security tools. Consider the F-score of Schonlau et al.’s raw data in Table 12. The system administrator can tell that when , the correctly detected masquerade activity should be almost five times as frequent as errors; this is the system administrators greatest area of concern. A corporate executive might be concerned about the effect all four categories could have on the enterprise’s performance; thus, TOR would be most relevant. Consider the TOR score of Schonlau et al.’s raw data in Table 12. The executive can tell that when , there will be over 13 correctly classified events for every misclassification. Based on these values, both persons might decide that performance is acceptable. JPT tuning, however, changes the picture considerably. The executive will see accuracy triple, but the system administrator will see a decrease in accuracy of more than three orders of magnitude. The executive and system administrator may now have different opinions.

Another problem with selecting an inappropriate summary statistic can be seen in Table 11. Not all measures have the same optimum threshold. An end user relying on an inappropriate summary statistic to determine a useful boundary for masquerade detection may be disappointed with their results.

After a classifier is selected, the two perspectives can lead to different system optimizations. When made available to end users, TAR and F-score values can help stakeholders such as executives and IT managers make more informed decisions. Since TAR/TOR and F-score/F-score may have different optimum boundaries, practitioners and decision makers may benefit from having both values reported for each optimum boundary over an rCS range. That way, end users will have an appreciation of the tradeoff associated with selecting a particular solution.

7. Conclusion

This paper is a first step in identifying the structure of CPD problems faced by end users. Using that structure, we characterize how CPD evaluation measures are relevant to end users and identify end user relevant evaluation tools. To that end, we have defined rCS’s importance to end user problems, identified measures that are efficacious for end users, and shown how JPT normalization and JPT tuning are useful for end user CPD evaluation.

Depending upon whether the end user is interested in the cumulative output or each individual CPD output, rCS is either an important factor or confounding. For maximum end user utility, research reports should include information efficacious for both problem types: (i)for “rCS is confounding” problems, end users need a summary statistic, and the underlying measurement suite, , . All three values are based on normalized JPTs. If the values used are from normalized JPTs, then and both equal one, thus are unnecessary. (ii)For “rCS is important” problems, end users must be able to tailor results to suit their individual rCS environments. We identify one appropriate summary statistic; the total accuracy odds ratio . Another, F-score, is already in use: , where is the relative weight of precision and recall: is the importance of precision relative to the importance of recall. End users can apply JPT tuning to tailor results for their environment. To do so, they will require the base JPT values (). Consolidating these findings, we propose that end users will be better served if research reports include PPV, NPV, EPA (or , if it is prevalent in the domain), and the four normalized base JPT values.

Future work will continue to develop a CPD problem structure. The disparity between TAR and F-score suggests that at least one more characteristic exists. Also, without compensating for the effect of the shift in optimum boundary, JPT tuning does not fully address the end user’s need to tailor research results. We will be considering means of addressing that deficiency.


A. Restating in Terms of JPT Values

As defined, where Substituting, we have Multiplying and creating common denominators,

Multiplying numerator and denominator by leaves

B. Restating DP in Terms of JPT Values

where Combining the logs, we get Then, substituting for and , Substituting for sensitivity and specificity, Multiplying top and bottom by , we are left with

C. Derivation of Normalized MCC Equation

An important side note is that MCC, as commonly calculated, is not rCS-invariant as is sometimes reported [2834]; it must use normalized JPT values (as in Table 13).

Substituting the normalized JPT values in (C.1) and collecting terms, the -invariant MCC is Equation (C.2) can be used in lieu of normalizing JPTs prior to calculating MCC.

D. Measures with Intrinsic rCS Invariance

Although the AUC, Youden index and DOR/DP are distinctly different measures; they all have one key similarity: normalized input. The AUC and Youden index both are , and since and are conditional probabilities and , likewise, and are conditional probabilities and . If, in the JPT, we replace by , by , by , by , then the marginal totals and are replaced by 1 s and becomes 2. This is shown in Table 15. Since the two marginal totals representing class size are equal, this process compensates for rCS: the CPD output JPTs have been normalized. In this paper, calculations and discussion using the rCS invariant JPT form shown in Table 14 will refer to “normalized” versions. Any discussions not referring to “normalization” are of measures using the “raw” JPT form as presented in Section 3, Table 1.

Regardless of the actual test set rCSs, the input values for the AUC and Youden index incorporate JPT normalization. Although not as evident, this is also true for DOR and DP. Any JPT can be defined in terms of the and . This is illustrated in Table 14. Using Table 14 definitions, After simplification, Thus, we find that DOR and DP are based on normalized JPTs as well.

From the literature, we see that MCC is rCS-invariant when calculated on normalized JPTs. Presumably, other rCS-sensitive measures will be rCS-invariant when calculated on normalized JPTs as well. We tested this hypothesis by calculating accuracy, F-score, and MCC values on normalized versions. Figure 11 displays the peak Accuracy rate and F-score on normalized JPTs and compares them to the output of the established rCS-invariant measures, AUC, DOR,29 and Youden index (DP, being just a log expression of DOR was left out.) The graphs are provided solely to compare their response to rCS. Any conclusions from Figure 11 beyond that must be made with care.

Figure 11 brings out some interesting points. (i)  Confidence interval response to rCS seems to fall into two categories. All of the normalized measures (including AUC, Youden index, DOR, and DP) have relatively stable CIs below . Above , there is an observable trend away from the stable value. This is due to a well-known issue with absolute sample size related to the strong law of large numbers. In our tests, the problem became statistically significant when the smaller sample had less than four hundred members.For normalized accuracy rate, Youden index, normalized F-score, and normalized MCC, the 90% confidence interval generally increases as rCS increases. Analyzing the CIs is difficult because (all but DOR) are measured on scales with an upper bound, their scales are not linear. The CI changes observed, however, are consistent with expectations. In general, as the positive class size decreases, normalization magnifies any changes in and far more than normalization of the negative class makes offsetting reductions (the positive class decreases by a factor of , while the negative class increases by a factor of less than ). (ii) Measure families have been found in the summary statistics evaluated. As discussed earlier, DOR and DP are related. The test also reveals a similarity between the normalized accuracy rate and Youden index: so that Thus, we see that normalized accuracy rate and Youden index are related. (iii) JPT normalization can inflate reported process accuracy. Each graph in Figure 11 exhibits rCS stability when . However, when , rCS invariance seems to weaken. This turns out to be a function of the absolute size of the smaller class and is a consequence of the strong law of large numbers. As class sample size decreases, its representation of the source population decreases. The problem is that as sample size decreases, distribution tails lose their definition. When a sample size is magnified by JPT normalization, the undefined tails do not reappear, thus causing the sample to represent a source population with a smaller variance. This means the class overlap is underrepresented. Since process accuracy is inversely related to class overlap, a reduction in estimated class overlap will result in process accuracy overestimation. In our tests, the difference became statistically significant when sample sizes fell below four hundred members.Violating the strong law of large numbers also affects the optimum boundary. As the apparent source population variance decreases, the boundary shifts toward that class. This can be seen in all of the contour graphs. In order to increase rCS, our protocol decreases . has the lower mean; thus, as rCS increases, the calculated optimum boundary starts shifting toward . In our tests, when , the shift becomes statistically significant.


The authors are thankful for the insightful comments in the early days of this work by Dr. Lynda Ballou, Mathematics Department, NM, USA Institute of Mining and Technology, Socorro, New Mexico. They are also indebted to Dr. Andrew Barnes, Applied Statistics Lab, General Electric Global Research, Niskayuna, NY, USA for taking the time to discuss this work. The journal reviewer’s comments strengthened the paper considerably.


  1. There are two levels of tool development. If development is “basic research,” then evaluation is application-agnostic. If it is “applied research,” then the focus is application-specific and evaluation needs tend to align with practitioner needs. For the purpose of this discussion, researchers do basic research; end users consist of practitioners and applied researchers.
  2. CPD are a subset of the more general group of categorical problems. Our investigations apply to both.
  3. The measure suite members quantify some particular aspect of CPD performance, thus providing greater CPD performance detail. These measure suite elements tend to be monotonic; thus, they are difficult to use individually to quantify overall CPD performance.
  4. If the summary statistic only generates a single value, it is by definition . can also be a range. If there are multiple s, they need not be continuous.
  5. For example, measures used for CPD evaluation have been tested for invariance to various JPT perturbations [6]. Sokolova and Lapalme claim to be the first to comprehensively assess invariance to JPT perturbations; no boundary invariance assessments are known and only one summary statistic, AUC, claims boundary invariance. This study observes boundary effect on the metrics, but does not look for a basis for boundary invariance. This is left for future work.
  6. The receiver operating characteristic originated in signal theory and gained its name from that problem domain. ROC, however, is now commonly used to analyze categorical data represented in JPTs. Although “receiver operating characteristic” may be the most commonly seen label in the literature, “relative operating characteristic,” being less domain specific, has been proposed as a more appropriate name.
  7. End user knowledge regarding actual input population probabilities for their environment may vary. As pointed out later, such information may be either important or confounding.
  8. The example in Section 6 presents a case with two physician’s offices. One was a general practitioner, where patients tested for RA had an rCS of 0.01 (). The other was a rheumatologist. In that office, patients tested for RA had an rCS of 100 ().
  9. MCC is often touted as being rCS-invariant. This, however, is only true in a special case. This and related implications are discussed in Section 5.
  10. IC is also considered to be rCS-invariant. As with MCC, this is only true in a special case.
  11. Or their complements, the probability that desired observations are incorrectly identified and the probability that desired observations are mistakenly labeled as undesired.
  12. A Google scholar search for “Matthews correlation coefficient” turned up well over one thousand articles. The publications cited are but a small sample.
  13. Using the results shown in Figures 5(a) and 5(b) as an example, if a test was run on a sample with on raw JPTs, the and . Recalculating MCC for the normalized JPT observed at and , results in . However, the actual peak is .
  14. Independence is a highly overloaded term. In this context, it means that any change to will not affect .
  15. DOR and DP are seen frequently in medical studies. In this problem domain, the inappropriate boundary risk may not always be present. The risk would exist in a study of heart attacks versus cholesterol levels; cholesterol level is a continuous variable. However, in a study of heart attacks versus family history, family history could be binary (a close relative died/did not die). In this type of test, boundary sensitivity is not an issue; care must be taken, however, in test design. Just by changing the test to a count (“how many close relatives died/did not die,” for instance) causes the problem to reappear.
  16. and are measured on different scales than the other summary statistics. In order to facilitate comparison, was converted from an “odds ratio” type measure (bounded by ) to a “probability” type measure (bounded by ). The relation between the two forms is
  17. There is a similar measurement suite the “detection error tradeoff” (DET) [56]. DET plots the missed detection rate instead of the correct detection rate on the axis. Since the two values are each other's complement, comments herein regarding ROC apply equally to DET. Interestingly, DET is plotted using log scales. This is a real challenge for measures with a lower bound of zero.
  18. Since all of the inherently rCS-invariant measures studies have as measurement suites, the ROC curve could be presented for each of them as well.
  19. We noticed a similar effect on the measure's values. The values started becoming overly optimistic (once again, excepting DOR, the values of which dropped). The cause turned out to be a well-known issue with absolute sample size. The effect became significant when class ’s size fell below 400 elements.
  20. Pdf standardization is confounding when evaluating a problem where rCS is important; thus, standardization is not appropriate for all problems. The set of all CPD problems is greater than the set of problems where pdf standardization is useful. Likewise, the set of all pdf comparisons includes problems with other than overlapping (or potentially overlapping) probability distribution functions, hence, the CPD problem domain intersects with the pdf comparison domain, but is neither a superset nor a subset.
  21. This expression does not require that initially. With the exception of or equaling zero, any JPT can be transformed (tuned) from one rCS to another.
  22. There may be a solution to this deficiency; we will investigate this in future work.
  23. As nicely summarized by [57], meta-analysis is a statistical technique for combining the findings from independent studies. Meta-analysis is most often used to assess the clinical effectiveness of healthcare interventions; it does this by combining data from two or more randomized control trials. Meta-analysis of trials provides a precise estimate of treatment effect, giving due weight to the size of the different studies included. The validity of the meta-analysis depends on the quality of the systematic review on which it is based. Good meta-analyses aim for complete coverage of all relevant studies, look for the presence of heterogeneity, and explore the robustness of the main findings using sensitivity analysis.
  24. Anti-CCP refers to an assay using cyclic citrullinated peptide (CCP) to detect the anti-CCP antibody.
  25. RF is an initialism referring to rheumatoid factor, an antibody used as a marker for RA.
  26. On a single tailed test as used here, only one bound is relevant; thus, the bound indicates a 97.5% confidence.
  27. In a CPD setting where rCS is important, JPT tuning enables a capability previously unavailable: sensitivity analysis. For the practitioner, this means that CPD performance can be evaluated for the expected rCS. Moreover, CPD performance can be identified over the rCS range the practitioner might expect.
  28. The implications of the difference between TAR and F-score will be addressed in future work.
  29. All of the other measures are bound. In order to facilitate comparison, DOR was transformed from an “odds” format to the equivalent “probability” format.