Table of Contents
Advances in Anesthesiology
Volume 2015, Article ID 562378, 6 pages
Review Article

Mutations in Sodium Channel Gene SCN9A and the Pain Perception Disorders

1Center for Anesthesiology and Reanimatology, Clinical Center Niš, Bulevar Dr. Zorana Djindjića 48, 18000 Niš, Serbia
2Department for Anesthesia and Intensive Care, School of Medicine, University of Niš, Bulevar Dr. Zorana Djindjića 81, 18000 Niš, Serbia

Received 29 September 2014; Accepted 8 February 2015

Academic Editor: Sorin J. Brull

Copyright © 2015 Danica Marković et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Voltage-gated sodium channels (NaV) play a crucial role in development and propagation of action potentials in neurons and muscle cells. NaV1.7 channels take a special place in modern science since it is believed that they contribute to nerve hyperexcitability. Mutations of the gene SCN9A, which codes the α subunit of NaV1.7 channels, are associated with pain perception disorders (primary erythermalgia, congenital analgesia, and paroxysmal pain disorder). It is considered that the SCN9A gene mutations may cause variations in sensitivity to pain, from complete insensitivity to extreme sensitivity. Further research of the SCN9A gene polymorphism influence on pain sensitivity is essential for the understanding of the pathophysiology of pain and the development of the appropriate targeted pain treatment.