Table of Contents
Advances in Andrology
Volume 2014, Article ID 307950, 11 pages
Review Article

Chlamydial Infection and Its Role in Male Infertility

1Division of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, 60 Murray Street, 6th Floor, Toronto, ON, Canada M5T 3L9
2Division of Urology, Department of Surgery, University of Saskatchewan, 105 Administration Place, Saskatoon, SK, Canada S7N 5A1
3Faculty of Medicine, Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5T 3L9
4Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5T 3L9

Received 20 November 2013; Revised 28 February 2014; Accepted 30 April 2014; Published 1 June 2014

Academic Editor: Mónica Hebe Vazquez-Levin

Copyright © 2014 Mary K. Samplaski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Chlamydia trachomatis is an established cause of tubal factor infertility; however its role in male fertility is not as clear. We sought to determine the prevalence of Chlamydia in infertile men and evaluate its impact on male reproductive potential. Materials and Methods. We compared the incidence of Chlamydia in our infertile male population with that reported in the literature. We then reviewed the impact of Chlamydia infection on male fertility. Results. The incidence of Chlamydia infection in our population of infertile men was 0.3%. There is considerable variability in the reported incidence, likely due to variation in the population studied, and detection technique. The optimal testing method and sample are presently unclear. The effect of Chlamydia on male reproductive function is also variable in the literature, but appears to be relatively minimal and may be related primarily to sperm DNA fragmentation or female partner transmission. Conclusions. The prevalence of Chlamydia in the infertile male population is low and routine testing is not supported by the literature. For high-risk infertile men, nucleic acid testing of urine +/− semen is the most sensitive method to detect Chlamydia. A validated testing system for semen needs to be developed, so that a standardized methodology can be recommended. In this way the full implications of Chlamydia on male fertility can be elucidated.