Table of Contents
Advances in Andrology
Volume 2015, Article ID 613259, 7 pages
http://dx.doi.org/10.1155/2015/613259
Research Article

Prevalence of Hypogonadism in a Male Population below 60 Years of Age with Metabolic Syndrome

1Department of Endocrinology, University of Chile, San Borja Arriaran Hospital, Santiago, Chile
2Department of Medicine, University of Chile, San Borja Arriaran Hospital, Santiago, Chile
3Vespucio Clinic, Santiago, Chile
4University of Chile, Santiago, Chile

Received 12 January 2015; Revised 21 May 2015; Accepted 25 May 2015

Academic Editor: Gaffari Türk

Copyright © 2015 Rafael Ríos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. K. Singh, R. Goyal, and D. D. Pratyush, “Is hypoandrogenemia a component of metabolic syndrome in males?” Experimental and Clinical Endocrinology and Diabetes, vol. 119, no. 1, pp. 30–35, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Beltrán-Sánchez, M. O. Harhay, M. M. Harhay, and S. McElligott, “Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999–2010,” Journal of the American College of Cardiology, vol. 62, no. 8, pp. 697–703, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Chackrewarthy, D. Gunasekera, A. Pathmeswaren et al., “A comparison between revised NCEP ATP III and IDF definitions in diagnosing metabolic syndrome in an urban Sri Lankan population: the ragama health study,” ISRN Endocrinology, vol. 2013, Article ID 320176, 7 pages, 2013. View at Publisher · View at Google Scholar
  4. E. Acosta Garcia, “Vigencia del Síndrome Metabólico,” Acta Bioquímica Clínica Latinoamericana, vol. 45, no. 3, 2011. View at Google Scholar
  5. J. Escobedo, H. Schargrodsky, B. Champagne et al., “Prevalence of the Metabolic Syndrome in Latin America and its association with sub-clinical carotid atherosclerosis: the CARMELA cross sectional study,” Cardiovascular Diabetology, vol. 8, article 52, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. A. A. B. Valenzuela, A. Maíz, P. Margozzini et al., “Prevalencia de síndrome metabólico en población adulta Chilena: Datos de la Encuesta Nacional de Salud 2003,” Revista Médica de Chile, vol. 138, pp. 707–714, 2010. View at Google Scholar
  7. P. M. Rao, D. M. Kelly, and T. H. Jones, “Testosterone and insulin resistance in the metabolic syndrome and T2DM in men,” Nature Reviews Endocrinology, vol. 9, no. 8, pp. 479–493, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. P. R. Costanzo, S. M. Suárez, H. E. Scaglia, C. Zylbersztein, L. E. Litwak, and P. Knoblovits, “Evaluation of the hypothalamic-pituitary-gonadal axis in eugonadal men with type 2 diabetes mellitus,” Andrology, vol. 2, no. 1, pp. 117–124, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Tchernof and J.-P. Després, “Pathophysiology of human visceral obesity: an update,” Physiological Reviews, vol. 93, no. 1, pp. 359–404, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Hajamor, J.-P. Després, C. Couillard et al., “Relationship between sex hormone-binding globulin levels and features of the metabolic syndrome,” Metabolism: Clinical and Experimental, vol. 52, no. 6, pp. 724–730, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. D. E. Laaksonen, L. Niskanen, K. Punnonen et al., “Sex hormones, inflammation and the metabolic syndrome: a population-based study,” European Journal of Endocrinology, vol. 149, no. 6, pp. 601–608, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. S. M. Gapstur, P. H. Gann, P. Kopp, L. Colangelo, C. Longcope, and K. Liu, “Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study,” Cancer Epidemiology Biomarkers and Prevention, vol. 11, no. 10, pp. 1041–1047, 2002. View at Google Scholar · View at Scopus
  13. G. B. Phillips, T. Jing, and S. B. Heymsfield, “Relationships in men of sex hormones, insulin, adiposity, and risk factors for myocardial infarction,” Metabolism: Clinical and Experimental, vol. 52, no. 6, pp. 784–790, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Hofstra, S. Loves, B. van Wageningen, J. Ruinemans-Koerts, I. Janssen, and H. de Boer, “High prevalence of hypogonadotropic hypogonadism in men referred for obesity treatment,” Netherlands Journal of Medicine, vol. 66, no. 3, pp. 103–109, 2008. View at Google Scholar · View at Scopus
  15. S. Y. Kalinchenko, Y. A. Tishova, G. J. Mskhalaya, L. J. G. Gooren, E. J. Giltay, and F. Saad, “Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study,” Clinical Endocrinology, vol. 73, no. 5, pp. 602–612, 2010, Erratum to Clinical Endocrinology, vol. 75, no. 2, pp. 275, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. D. M. Kelly and T. H. Jones, “Testosterone: a vascular hormone in health and disease,” Journal of Endocrinology, vol. 217, no. 3, pp. R47–R71, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. K. G. M. M. Alberti, P. Zimmet, and J. Shaw, “Metabolic syndrome—a new world-wide definition. A consensus statement from the International Diabetes Federation,” Diabetic Medicine, vol. 23, no. 5, pp. 469–480, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. C. E. Ejike and I. I. Ijeh, “Obesity in young-adult Nigerians: variations in prevalence determined by anthropometry and bioelectrical impedance analysis, and the development of % body fat prediction equations,” International Archives of Medicine, vol. 5, article 22, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. V. Martín Moreno, B. Gómez Gandoy, M. Antoranz González, S. Fernández Herranz, A. Gómez De La Cámara, and M. de Oya Otero, “Validation of the OMRON BF 300 monitor for measuring body fat by bioelectric impedance,” Atencion Primaria, vol. 28, no. 3, pp. 174–181, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. L. P. Ly, G. Sartorius, L. Hull et al., “Accuracy of calculated free testosterone formulae in men,” Clinical Endocrinology, vol. 73, no. 3, pp. 382–388, 2010. View at Publisher · View at Google Scholar
  21. http://www.issam.com/free%20calculator%20testosterone.
  22. S. Bashin, M. Pencina, G. K. Jasuja et al., “Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the framingham heart study and applied to three geographically distinct cohorts,” The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 8, pp. 2430–2439, 2011. View at Publisher · View at Google Scholar
  23. D. A. Paduch, R. E. Brannigan, E. F. Fuchs, E. D. Kim, J. L. Marmar, and J. I. Sandlow, “The laboratory diagnosis of testosterone deficiency,” Urology, vol. 83, no. 5, pp. 980–988, 2014. View at Publisher · View at Google Scholar
  24. A. Vermeulen, L. Verdonck, and J. M. Kaufman, “A critical evaluation of simple methods for the estimation of free testosterone in serum,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 10, pp. 3666–3672, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Rodríguez Tolrà, A. Domínguez García, J. Torremadé Barreda, D. Rodríguez Pérez, and E. Franco Miranda, “Importance of calculated free testosterone in the diagnosis of testosterone deficiency syndrome,” Revista Internacional de Andrologia, vol. 8, no. 2, pp. 85–88, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. W. A. Herman, A. Krzoska, E. Pawliczak, M. Roszak, and K. Łacka, “Evaluation of relationships between plasma androgens level and clinical signs of hipoandrogenism according to age and comorbidity of metabolic syndrome in men,” Polski Merkuriusz Lekarski, vol. 36, no. 211, pp. 16–21, 2014. View at Google Scholar
  27. D. Kapoor, H. Aldred, S. Clark, K. S. Channer, and T. H. Jones, “Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity,” Diabetes Care, vol. 30, no. 4, pp. 911–917, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. O. A. Ogbera, C. Sonny, F. Olufemi, and A. Wale, “Hypogonadism and subnormal total testosterone levels in men with type 2 diabetes mellitus,” Journal of the College of Physicians and Surgeons Pakistan, vol. 21, no. 9, pp. 517–521, 2011. View at Google Scholar · View at Scopus
  29. S. Dhindsa, S. Prabhakar, M. Sethi, A. Bandyopadhyay, A. Chaudhuri, and P. Dandona, “Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 11, pp. 5462–5468, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. E. Selvin, M. Feinleib, L. Zhang et al., “Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III),” Diabetes Care, vol. 30, no. 2, pp. 234–238, 2007. View at Publisher · View at Google Scholar
  31. A. Gray, H. A. Feldman, J. B. McKinlay, and C. Longcope, “Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study,” Journal of Clinical Endocrinology and Metabolism, vol. 73, no. 5, pp. 1016–1025, 1991. View at Publisher · View at Google Scholar · View at Scopus
  32. G. R. Dohle, S. Arver, C. Bettocchi, S. Kliesch, M. Punab, and W. de Ronde, Guidelines on Male Hypogonadism, European Association of Urology, Arnhem, The Netherlands, 2012.
  33. A. Tajar, I. T. Huhtaniemi, T. W. O'Neill et al., “Characteristics of androgen deficiency in late-onset hypogonadism: results from the European Male Aging Study (EMAS),” The Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 5, pp. 1508–1516, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. R. Haring, T. Ittermann, H. Völzke et al., “Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in Pomerania,” Aging Male, vol. 13, no. 4, pp. 247–257, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Gatti, E. Mandosi, M. Fallarino et al., “Metabolic syndrome and erectile dysfunction among obese non-diabetic subjects,” Journal of Endocrinological Investigation, vol. 32, no. 6, pp. 542–345, 2009. View at Publisher · View at Google Scholar
  36. B. D. Anawalt, J. M. Hotaling, T. J. Walsh, and A. M. Matsumoto, “Performance of total testosterone measurement to predict free testosterone for the biochemical evaluation of male hypogonadism,” Journal of Urology, vol. 187, no. 4, pp. 1369–1373, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Grossmann, M. C. Thomas, S. Panagiotopoulos et al., “Low testosterone levels are common and associated with insulin resistance in men with diabetes,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 5, pp. 1834–1840, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Biswas, D. Hampton, R. G. Newcombe, and D. A. Rees, “Total and free testosterone concentrations are strongly influenced by age and central obesity in men with type 1 and type 2 diabetes but correlate weakly with symptoms of androgen deficiency and diabetes-related quality of life,” Clinical Endocrinology, vol. 76, no. 5, pp. 665–673, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Aslan, O. Guzel, M. Balci, A. Tuncel, M. Yildiz, and A. Atan, “The impact of metabolic syndrome on serum total testosterone level in patients with erectile dysfunction,” Aging Male, vol. 17, no. 2, pp. 76–80, 2014. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Verdich, P. Barbe, M. Petersen et al., “Changes in body composition during weight loss in obese subjects in the NUGENOB study: comparison of bioelectrical impedance vs. dual-energy X-ray absorptiometry,” Diabetes and Metabolism, vol. 37, no. 3, pp. 222–229, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Garaulet, F. Perez-Llamas, T. Fuente, S. Zamora, and F. J. Tebar, “Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones,” European Journal of Endocrinology, vol. 143, no. 5, pp. 657–666, 2000. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Tena-Sempere, L. Pinilla, L. C. González, C. Diéguez, F. F. Casanueva, and E. Aguilar, “Leptin inhibits testosterone secretion from adult rat testis in vitro,” Journal of Endocrinology, vol. 161, no. 2, pp. 211–218, 1999. View at Google Scholar
  43. A. M. Isidori, M. Caprio, F. Strollo, C. Moretti, G. Frajese, and A. Fabbri, “Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 10, pp. 3673–3680, 1999. View at Google Scholar · View at Scopus
  44. N. Pitteloud, M. Hardin, A. A. Dwyer et al., “Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men,” The Journal of Clinical Endocrinology & Metabolism, vol. 90, no. 5, pp. 2636–2641, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. J. C. Bruning, D. Gautam, D. J. Burks et al., “Role of brain insulin receptor in control of body weight and reproduction,” Science, vol. 289, no. 5487, pp. 2122–2125, 2000. View at Publisher · View at Google Scholar · View at Scopus
  46. T. Lin, J. Haskell, N. Vinson, and L. Terracio, “Characterization of insulin and insulin-like growth factor I receptors of purified Leydig cells and their role in steroidogenesis in primary culture: a comparative study,” Endocrinology, vol. 119, no. 4, pp. 1641–1647, 1986. View at Publisher · View at Google Scholar
  47. M. Maggio, F. Lauretani, G. P. Ceda et al., “Estradiol and metabolic syndrome in older Italian men: the InCHIANTI study,” Journal of Andrology, vol. 31, no. 2, pp. 155–162, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. G. Williams, “Aromatase up-regulation, insulin and raised intracellular oestrogens in men, induce adiposity, metabolic syndrome and prostate disease, via aberrant ER-α and GPER signalling,” Molecular and Cellular Endocrinology, vol. 351, no. 2, pp. 269–278, 2012. View at Publisher · View at Google Scholar · View at Scopus