Table of Contents
Advances in Biology
Volume 2014, Article ID 143023, 12 pages
http://dx.doi.org/10.1155/2014/143023
Review Article

GPCRs: Lipid-Dependent Membrane Receptors That Act as Drug Targets

CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India

Received 20 July 2014; Accepted 6 September 2014; Published 2 October 2014

Academic Editor: Luis Loura

Copyright © 2014 Amitabha Chattopadhyay. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [45 citations]

The following is the list of published articles that have cited the current article.

  • Hirak Chakraborty, and Amitabha Chattopadhyay, “Excitements and Challenges in GPCR Oligomerization: Molecular Insight from FRET,” ACS Chemical Neuroscience, pp. 141102120531000, 2014. View at Publisher · View at Google Scholar
  • Mohammad Jafurulla, and Amitabha Chattopadhyay, “Sphingolipids in the function of G protein-coupled receptors,” European Journal Of Pharmacology, vol. 763, pp. 241–246, 2015. View at Publisher · View at Google Scholar
  • Mohammad Jafurulla, and Amitabha Chattopadhyay, “Sphingolipids in the function of G protein-coupled receptors,” European Journal of Pharmacology, 2015. View at Publisher · View at Google Scholar
  • Kristyna Pluhackova, and Rainer A. Böckmann, “Biomembranes in atomistic and coarse-grained simulations,” Journal of Physics: Condensed Matter, vol. 27, no. 32, pp. 323103, 2015. View at Publisher · View at Google Scholar
  • Durba Sengupta, and Amitabha Chattopadhyay, “Molecular dynamics simulations of GPCR–cholesterol interaction: An emerging paradigm,” Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015. View at Publisher · View at Google Scholar
  • Arunima Chaudhuri, and Amitabha Chattopadhyay, “Molecular Anatomy of an Ion Channel Explored Utilizing Fluorescence Spectroscopy,” Reviews in Fluorescence 2015, vol. 8, pp. 353–367, 2015. View at Publisher · View at Google Scholar
  • Swarna M. Patra, Sudip Chakraborty, Ganesh Shahane, Xavier Prasanna, Durba Sengupta, Prabal K. Maiti, and Amitabha Chattopadhyay, “ Differential dynamics of the serotonin 1A receptor in membrane bilayers of varying cholesterol content revealed by all atom molecular dynamics simulation ,” Molecular Membrane Biology, vol. 32, no. 4, pp. 127–137, 2015. View at Publisher · View at Google Scholar
  • Aiswarya B. Pawar, Xavier Prasanna, and Durba Sengupta, “Effect of Lipid Bilayer Composition on Membrane Protein Association,” 2015. View at Publisher · View at Google Scholar
  • Durba Sengupta, Manali Joshi, Chaitanya A. Athale, and Amitabha Chattopadhyay, “What can simulations tell us about GPCRs: integrating the scales,” 2015. View at Publisher · View at Google Scholar
  • Amitabha Chattopadhyay, Bhagyashree D. Rao, and Md. Jafurulla, “Solubilization of G Protein-Coupled Receptors: A Convenient Strategy to Explore Lipid–Receptor Interaction,” 2015. View at Publisher · View at Google Scholar
  • G. Aditya Kumar, Saptarshi Roy, Md. Jafurulla, Chitra Mandal, and Amitabha Chattopadhyay, “Statin-induced chronic cholesterol depletion inhibits Leishmania donovani infection: Relevance of optimum host membrane cholesterol,” Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1858, no. 9, pp. 2088–2096, 2016. View at Publisher · View at Google Scholar
  • Xavier Prasanna, Md. Jafurulla, Durba Sengupta, and Amitabha Chattopadhyay, “The Ganglioside GM1 Interacts with the Serotonin1A Receptor via the Sphingolipid Binding Domain,” Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016. View at Publisher · View at Google Scholar
  • Xavier Prasanna, Durba Sengupta, and Amitabha Chattopadhyay, “Cholesterol-dependent Conformational Plasticity in GPCR Dimers,” Scientific Reports, vol. 6, pp. 31858, 2016. View at Publisher · View at Google Scholar
  • Juan H. Bolivar, Juan C. Muñoz-García, Tomas Castro-Dopico, Patricia M. Dijkman, Phillip J. Stansfeld, and Anthony Watts, “Interaction of lipids with the neurotensin receptor 1,” Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1858, no. 6, pp. 1278–1287, 2016. View at Publisher · View at Google Scholar
  • Sai Prasad Pydi, Md. Jafurulla, Lisa Wai, Rajinder P. Bhullar, Prashen Chelikani, and Amitabha Chattopadhyay, “Cholesterol Modulates Bitter Taste Receptor Function,” Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016. View at Publisher · View at Google Scholar
  • Wataru Nemoto, Yoshihiro Yamanishi, Vachiranee Limviphuvadh, Akira Saito, and Hiroyuki Toh, “GGIP: Structure and sequence-based GPCR-GPCR interaction pair predictor,” Proteins: Structure, Function, and Bioinformatics, vol. 84, no. 9, pp. 1224–1233, 2016. View at Publisher · View at Google Scholar
  • M. Gertrude Gutierrez, Kylee S. Mansfield, and Noah Malmstadt, “The Functional Activity of the Human Serotonin 5-HT1A Receptor Is Controlled by Lipid Bilayer Composition,” Biophysical Journal, vol. 110, no. 11, pp. 2486–2495, 2016. View at Publisher · View at Google Scholar
  • G.Aditya Kumar, Md. Jafurulla, and Amitabha Chattopadhyay, “The membrane as the gatekeeper of infection: Cholesterol in host-pathogen interaction,” Chemistry and Physics of Lipids, 2016. View at Publisher · View at Google Scholar
  • G. Aditya Kumar, and Amitabha Chattopadhyay, “Cholesterol: An evergreen molecule in biology,” Biomedical Spectroscopy and Imaging, vol. 5, no. s1, pp. S55–S66, 2016. View at Publisher · View at Google Scholar
  • Bhagyashree D. Rao, Sandeep Shrivastava, and Amitabha Chattopadhyay, “Effect of local anesthetics on serotonin1A receptor function,” Chemistry and Physics of Lipids, 2016. View at Publisher · View at Google Scholar
  • Md. Jafurulla, Suman Bandari, Thomas J. Pucadyil, and Amitabha Chattopadhyay, “Sphingolipids Modulate the Function of Human Serotonin1A Receptors: Insights from Sphingolipid-deficient Cells,” Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016. View at Publisher · View at Google Scholar
  • Durba Sengupta, G. Aditya Kumar, and Amitabha Chattopadhyay, “Interaction of Membrane Cholesterol with GPCRs: Implications in Receptor Oligomerization,” G-Protein-Coupled Receptor Dimers, pp. 415–429, 2017. View at Publisher · View at Google Scholar
  • Shalmali Kharche, Manali Joshi, Durba Sengupta, and Amitabha Chattopadhyay, “Membrane-induced organization and dynamics of the N-terminal domain of chemokine receptor CXCR1: insights from atomistic simulations,” Chemistry and Physics of Lipids, 2017. View at Publisher · View at Google Scholar
  • V. B. Arakelyan, V. P. Danko, and R. P. Grigoryan, “Influence of the external noise intensity on the kinetics of ligands binding to receptors,” Journal of Contemporary Physics (Armenian Academy of Sciences), vol. 52, no. 1, pp. 70–75, 2017. View at Publisher · View at Google Scholar
  • Jessica A. Scarborough, John R. Paul, and Juliet V. Spencer, “Evolution of the ability to modulate host chemokine networks via gene duplication in human cytomegalovirus (HCMV),” Infection, Genetics and Evolution, 2017. View at Publisher · View at Google Scholar
  • Md. Jafurulla, and Amitabha Chattopadhyay, “Structural Stringency of Cholesterol for Membrane Protein Function Utilizing Stereoisomers as Novel Tools: A Review,” Cholesterol Homeostasis, vol. 1583, pp. 21–39, 2017. View at Publisher · View at Google Scholar
  • Bhagyashree D. Rao, Sandeep Shrivastava, and Amitabha Chattopadhyay, “Hydrophobic Mismatch in Membranes: When the Tail Matters,” Membrane Organization and Dynamics, vol. 20, pp. 375–387, 2017. View at Publisher · View at Google Scholar
  • Parijat Sarkar, and Amitabha Chattopadhyay, “Solubilization of the Serotonin 1A Receptor Monitored Utilizing Membrane Dipole Potential,” Chemistry and Physics of Lipids, 2017. View at Publisher · View at Google Scholar
  • Md. Jafurulla, Aswan Nalli, and Amitabha Chattopadhyay, “Membrane Cholesterol Oxidation in Live Cells Enhances the Function of Serotonin1A Receptors,” Chemistry and Physics of Lipids, 2017. View at Publisher · View at Google Scholar
  • Borislav Angelov, and Angelina Angelova, “Nanoscale clustering of the neurotrophin receptor TrkB revealed by super-resolution STED microscopy,” Nanoscale, 2017. View at Publisher · View at Google Scholar
  • Parijat Sarkar, and Amitabha Chattopadhyay, “GFP fluorescence: A few lesser-known nuggets that make it work,” Journal of Biosciences, 2018. View at Publisher · View at Google Scholar
  • Sreetama Pal, Ramdas Aute, Parijat Sarkar, Shroddha Bose, Mandar V. Deshmukh, and Amitabha Chattopadhyay, “Constrained dynamics of the sole tryptophan in the third intracellular loop of the serotonin 1a receptor,” Biophysical Chemistry, 2018. View at Publisher · View at Google Scholar
  • Durba Sengupta, Xavier Prasanna, Madhura Mohole, and Amitabha Chattopadhyay, “Exploring GPCR–Lipid Interactions by Molecular Dynamics Simulations: Excitements, Challenges, and the Way Forward,” The Journal of Physical Chemistry B, 2018. View at Publisher · View at Google Scholar
  • Gopinath Viswanathan, Md. Jafurulla, G. Aditya Kumar, Tirumalai R. Raghunand, and Amitabha Chattopadhyay, “Macrophage Sphingolipids are Essential for the Entry of Mycobacteria,” Chemistry and Physics of Lipids, 2018. View at Publisher · View at Google Scholar
  • Ruyin Cao, Alejandro Giorgetti, Andreas Bauer, Bernd Neumaier, Giulia Rossetti, and Paolo Carloni, “Role of Extracellular Loops and Membrane Lipids for Ligand Recognition in the Neuronal Adenosine Receptor Type 2A: An Enhanced Sampling Simulation Study,” Molecules, vol. 23, no. 10, pp. 2616, 2018. View at Publisher · View at Google Scholar
  • Hirak Chakraborty, Md. Jafurulla, Andrew H. A. Clayton, and Amitabha Chattopadhyay, “ Exploring oligomeric state of the serotonin 1A receptor utilizing photobleaching image correlation spectroscopy: implications for receptor function ,” Faraday Discussions, 2018. View at Publisher · View at Google Scholar
  • Sreetama Pal, and Amitabha Chattopadhyay, “Extramembranous Regions in G Protein-Coupled Receptors: Cinderella in Receptor Biology?,” The Journal of Membrane Biology, 2019. View at Publisher · View at Google Scholar
  • Sang-Min Nam, and Yong-Sun Maeng, “Wound Healing and Mucin Gene Expression of Human Corneal Epithelial Cells Treated with Deproteinized Extract of Calf Blood,” Current Eye Research, 2019. View at Publisher · View at Google Scholar
  • Giulia Rossetti, Achim Kless, Luhua Lai, Tiago F. Outeiro, and Paolo Carloni, “Investigating targets for neuropharmacological intervention by molecular dynamics simulations,” Biochemical Society Transactions, pp. BST20190048, 2019. View at Publisher · View at Google Scholar
  • G. Aditya Kumar, Parijat Sarkar, Md. Jafurulla, Shishu Pal Singh, Gunda Srinivas, Gopal Pande, and Amitabha Chattopadhyay, “ Exploring Endocytosis and Intracellular Trafficking of the Human Serotonin 1A Receptor ,” Biochemistry, 2019. View at Publisher · View at Google Scholar
  • Sarosh N. Fatakia, Parijat Sarkar, and Amitabha Chattopadhyay, “A Collage of Cholesterol Interaction Motifs in the Serotonin1A Receptor: An Evolutionary Implication for Differential Cholesterol Interaction,” Chemistry and Physics of Lipids, 2019. View at Publisher · View at Google Scholar
  • Sandeep Shrivastava, Md. Jafurulla, Shrish Tiwari, and Amitabha Chattopadhyay, “Identification of Sphingolipid-binding Motif in G Protein-coupled Receptors,” Biochemical and Biophysical Roles of Cell Surface Molecules, vol. 1112, pp. 141–149, 2019. View at Publisher · View at Google Scholar
  • Madhura Mohole, Xavier Prasanna, Durba Sengupta, and Amitabha Chattopadhyay, “Molecular Signatures of Cholesterol Interaction with Serotonin Receptors,” Biochemical and Biophysical Roles of Cell Surface Molecules, vol. 1112, pp. 151–160, 2019. View at Publisher · View at Google Scholar
  • Kouhei Yoshida, Satoru Nagatoishi, Daisuke Kuroda, Nanao Suzuki, Takeshi Murata, and Kouhei Tsumoto, “Phospholipid Membrane Fluidity Alters Ligand Binding Activity of a G Protein-Coupled Receptor by Shifting the Conformational Equilibrium,” Biochemistry, 2019. View at Publisher · View at Google Scholar
  • Md. Jafurulla, G. Aditya Kumar, Bhagyashree D. Rao, and Amitabha Chattopadhyay, “A Critical Analysis of Molecular Mechanisms Underlying Membrane Cholesterol Sensitivity of GPCRs,” Sino-Latin American Economic and Trade Relations, pp. 21–52, 2019. View at Publisher · View at Google Scholar