Advances in Biology / 2014 / Article / Fig 3

Review Article

Role of Orphan Nuclear Receptor DAX-1/NR0B1 in Development, Physiology, and Disease

Figure 3

A model of DAX-1 function during human adrenal development. DAX-1 represses steroidogenic gene expression in definitive zone cells, allowing for their proliferation and differentiation into glomerulosa, fasciculata, and reticularis zones. In the absence of functional DAX-1, abnormally early expression of steroidogenic genes is activated in the definitive zone and its proliferation is downregulated. Under these conditions, adrenal hypoplasia follows the physiological regression of the fetal zone after birth. From [35]. Copyright 2003 Endocrine Society.
582749.fig.003

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.