Research Article

Genomic Promoter Analysis Predicts Functional Transcription Factor Binding

Table 1

Prediction of in vivo occupancy by HNF1 and HNF4. Data from ChIP-chip studies (3) were integrated with CONFAC TFBS data and genes were separated randomly into training and test sets. The BAM MEI classifier was applied to the independent test set of 1349 genes to predict which class each gene belonged based on the TFBS patterns that were predictive of occupancy.

Predicted
ObservedHNF1 bothHNF1 hepHNF1 pancHNF4 bothHNF4 hepHNF4 pancUnboundTotal (obs)Sensitivity

HNF1 both5000003863%
HNF1 hep00000023230%
HNF1 panc00300071030%
HNF4 both0003500548939%
HNF4 hep0000140708417%
HNF4 panc0000041458648%
Unbound0006521036104999%
total (pred)50341194312381349
Specificity100%NA100%85%74%95%84%