Genomic Promoter Analysis Predicts Functional Transcription Factor Binding

Table 7

Prediction of in vivo occupancy by HNF1 and HNF4 by BAM MEI analysis using human-mouse genomic alignments instead of local pairwise BLAST alignments and a window size of zero.

Predicted
Observed	HNF1 both	HNF1 hep	HNF1 panc	HNF4 both	HNF4 hep	HNF4 panc	Unbound	Total (obs)	Sensitivity
HNF1 both	3	0	0	0	0	0	1	4	75%
HNF1 hep	0	1	0	0	0	0	18	19	5%
HNF1 panc	0	0	2	0	0	0	4	6	33%
HNF4 both	0	0	0	21	0	0	29	50	42%
HNF4 hep	0	0	0	0	16	0	82	98	16%
HNF4 panc	0	0	0	0	0	34	30	64	53%
Unbound	0	0	0	7	7	1	1259	1274	99%
Total (pred)	3	1	2	28	23	35	1423	1492
Specificity	100%	100%	100%	75%	67%	95%	88%