NCR-PCOPGene: An Exploratory Tool for Analysis of Sample-Classes Effect on Gene-Expression Relationships

Figure 2

Example 1: effect of classes derived from Q6 and SGC on GATA3 and AML1 expression. In the picture is shown the GATA3 (𝑥 axis) and AML1 (𝑦 axis) relationship, where the data-cloud shows the microarray experiments and the PCOP, connecting the POPs, describes the inner pattern of the expression relationship. The samples under-expressed in the Q6 and SGC relationship are coloured in red, and the samples over-expressed in the Q6 and SGC relationship are coloured in blue. This points out that the under-expression of Q6 and SGC implies an under-expression of GATA3 and AML1, but that an over-expression of Q6 and SGC does not always imply an over-expression of GATA3 and AML1. The data set represents the activity of 118 substances normalised for 60 cell-lines [16].