NCR-PCOPGene: An Exploratory Tool for Analysis of Sample-Classes Effect on Gene-Expression Relationships

Figure 3

Example 2: effect of over-expressed class from GATA3 and AML1 on SGC and Q6 expression: SGC (𝑥 axis) and Q6 (𝑦 axis) relationship, where the data-cloud shows the microarray experiments and the PCOP, connecting the POPs, describes the inner pattern of the expression relationship. The samples of the class representing the over-expression of GATA3 and AML1 are coloured. In this way, the four gene expressions are related, SGC and Q6 linearly, with GATA3 and AML1 maintaining a complex noncontinuous relationship with the other two. The data set represents the activity of 118 substances normalised for 60 cell-lines [16].