Research Article

Computational Design of a DNA- and Fc-Binding Fusion Protein

Table 1

Brownian dynamics simulation results.

model 𝑘 o n ( M−1 s−1 ) net charge rel. 𝑘 o n (WT)

WT 4 . 6 6 1 0 8 +5 1.000
Negative 0 −2 0.000
Seed 1 . 1 7 1 0 8 +5 0.251
JW15 3 . 0 6 1 0 8 +7 0.657
JW19 1 . 6 0 1 0 7 +3 0.034
JW56 4 . 6 1 1 0 7 +5 0.099
JW70 4 . 5 6 1 0 8 +5 0.978