An Integrated Framework to Model Cellular Phenotype as a Component of Biochemical Networks
Figure 1
Graphical depictions of best fit models identified using the fuzzy logic model-fitting procedure. Nodes representing genes are colored according to the phase of the cell cycle in which they reach peak expression. (Blue: G1 expression, red: M expression, green: M/G1 expression, white: phenotype/expression independent of cell cycle progression.) Edges between nodes represent inferred physical/genetic/indirect interactions between genes and gene products. Blue lines indicate positive interactions. Red lines indicate negative interactions. Dashed lines indicate biphasic interactions. (a) Best fit models for expression of each gene and the fraction of budding cells (phenotype) were identified by exhaustive search through the solution space using fuzzy logic. (b) Network diagram of integrated best fit models. Nodes are organized according to the phase of the cell cycle in which they reach peak expression.
