An Integrated Framework to Model Cellular Phenotype as a Component of Biochemical Networks

Figure 2

Observed and predicted fraction of budding cells at different time points in cell cycle progression. The red line and associated data points indicate the observed fraction of budding cells. The blue line indicates the fraction of budding cells predicted on the basis of gene expression. The green line indicates the fraction of budding cells predicted at convergence of the dynamic model. The fuzzy rules used to predict the fraction of budding cells are as follows: SIC1 (3,3,1); CLN3 (3,1,1); CLB6 (3,3,1); CLB1 (1,1,3); SWI5 (1,1,3).