Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides

<table>Van der Waals packing of V44 at the peptide-gp120 interface. (a) Enlargement of the interface. V44 of <i>β</i>-strand C<i>″</i> packs tightly into a pocket of the gp120 surface. (b) Replacement by alanine leads to loss of van der Waals packing. (c) Interaction energy of V44 with gp120. Total energy, electrostatic and van der Waals contribution are colored in black, gray, and blue, respectively.</table>

Advances in Bioinformatics

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Figure 5

Figure 5: Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides 