Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides
Figure 8
Optimization of mCD4-M. (a) mCD4-peptide-gp120 complex at the beginning (left) and after 100-ns MD simulation (right). For color-coding refer to Figure 4. (b) Visualization of engineered disulfide bond C65–C23 yielding a cyclic peptide with enhanced gp120-binding affinity.
