Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides

Table 1

Clashes of mCD4 with gp120. WHAT_CHECK analysis of clashes detected between mCD4 with gp120. All clashes > 0.8 Å are listed; bb and sc denote clashes by backbone or side-chain atoms. The clashes are visualized in Figure 2.

gp120		mCD4		Clash size [Å]
Region	Residue-ID	Residue-ID	Region
CD4-binding loop	S365 (sc)	G49 (bb)	C″D-loop insertion	1.95
β20/β21 (bridging sheet)	K429 (sc)	K42 (sc)	C′C″-loop insertion	1.64
β20/β21 (bridging sheet)	Q428 (bb)	K42 (sc)	C′C″-loop insertion	1.27
CD4-binding loop	I371 (sc)	V44 (sc)	C″ (F43/V44)	0.87
CD4-binding loop	S365 (sc)	G48 (bb)	C″	0.84