Research Article

ModEnzA: Accurate Identification of Metabolic Enzymes Using Function Specific Profile HMMs with Optimised Discrimination Threshold and Modified Emission Probabilities

Table 2

Conflicting annotations for the 22 EC numbers predicted as belonging to the P. falciparum genome by ModEnzA but not annotated in PlasmoDB.

EC No.SequenceKEGGPlasmoCyc

1.1.5.3PFC0275wFAD-dependent glycerol-3-phosphate dehydrogenase, putativeFAD-dependent glycerol-3-phosphate dehydrogenase, putative
1.17.7.1PF10_0221(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthaseMethylerythritol phosphate pathway
1.3.1.8PF11_0370
1.3.5.2PFF0160cUridine-5′-phosphate biosynthesis
2.1.1.48PF14_0156
2.3.1.180PFB0505c3-Oxoacyl-(acyl carrier protein) synthase III, putativeFatty acid biosynthesis initiation I
2.3.1.181MAL8P1.37Lipoyl(octanoyl) transferase
2.4.1.141MAL8P1.133Beta-1,4-N-acetylglucosaminyltransferaseDolichyl-diphosphooligosaccharide biosynthesis
2.7.12.1PF14_0431dual-specificity kinase
2.7.1.90PFI0755c6-phosphofructokinaseATP-dependent phosphofructokinase, putative
2.7.7.64PFE0875c
2.8.1.8MAL13P1.220Lipoic acid synthetase
3.1.13.4MAL8P1.104, PFE0980c
3.1.21.2PF13_0176
3.4.21.10PFE0340c, PF11_0149, MAL8P1.16, PF14_0110
3.5.1.88PFI0380c
3.6.1.1PF14_0541, PFL1700c, PFC0710w-a, PFC0710w-bInorganic pyrophosphataseInorganic pyrophosphatase, putative, V-type H(+)-translocating pyrophosphatase, putative
3.6.1.7PF11_0121
3.6.3.44PFE1150wABC transporter, putative
3.6.4.3PF14_0548
3.6.4.6PFC0140cVesicle-fusing ATPase
3.6.5.5PF10_0368Dynamin GTPase

“—”–Annotation not present in either PlasmoCyc or KEGG.