Research Article

ModEnzA: Accurate Identification of Metabolic Enzymes Using Function Specific Profile HMMs with Optimised Discrimination Threshold and Modified Emission Probabilities

Table 3

Three-digit annotations for the sequences selected from P. falciparum by Tier II and Tier III profiles.

GenePlasmoDB product description*PlasmoDB EC*ModEnzA ECEC description#

PF07_00594-nitrophenylphosphatase, putative3.1.3.-(Phosphoric monoester hydrolases.); 3.1.3.41 (4-nitrophenylphosphatase)T2-3.1.3.414-nitrophenylphosphatase
PF08_0108Pepsinogen, putative3.4.23.1T2-3.4.23.2Pepsin B
PF10_0329Aspartyl protease, putative; Plasmepsin VIINoneT2-3.4.23.2Pepsin B
PF11_0161Falcipain-2 precursor, putative3.4.22.-T3-3.4.22.32Stem bromelain
PF11_0162Falcipain-33.4.22.-T3-3.4.22.32Stem bromelain
PF11_0165Falcipain 2 precursor3.4.22.-T3-3.4.22.32Stem bromelain
PF11_0295Farnesyl pyrophosphate synthase, putative2.5.1.10 Geranyltranstransferase; 2.5.1.1 DimethylallyltranstransferaseT2-2.5.1.67Chrysanthemyl diphosphate synthase
PF14_0075Plasmepsin, putative3.4.23.38 (Plasmepsin I)T2-3.4.23.39Plasmepsin II
PF14_0076Plasmepsin 1 precursor3.4.23.38 (Plasmepsin I)T2-3.4.23.39Plasmepsin II
PF14_0077Plasmepsin 23.4.23.39 (Plasmepsin II)T2-3.4.23.39Plasmepsin II
PF14_0078HAP protein; Plasmepsin III3.4.23.-Aspartic endopeptidasesT2-3.4.23.39Plasmepsin II
PF14_0281Aspartyl protease, putativeNoneT2-3.4.23.2Pepsin B
PF14_0334NAD(P)H-dependent glutamate synthase, putative1.4.7.1 Glutamate synthase (ferredoxin);1.4.1.14 -Glutamate synthase (NADH)T2-1.4.1.14Glutamate synthase
PF14_0553Cysteine proteinase falcipain-1NoneT3-3.4.22.32Stem bromelain
PF14_0625Hypothetical protein3.4.2.3; Transferred entry: 3.4.17.4T2-3.4.23.2Pepsin B
PFC0495wAspartyl protease, putative3.4.23.- Aspartic endopeptidasesT2-3.4.23.2Pepsin B
PFF0530wTransketolase, putative2.2.1.1 TransketolaseT2-2.2.1.3Formaldehyde transketolase
PFI1125c3-oxoacyl-(acyl-carrier protein) reductase, putative1.1.1.100 (3-oxoacyl-[acyl-carrier-protein] reductase); 2.3.1.85 (Fatty-acid synthase)T2-1.1.1.140Sorbitol-6-phosphate 2-dehydrogenase

*Gene product descriptions and EC annotations obtained from PlasmoDB. #IUBMB EC description.