Generation and Analysis of Large-Scale Data-Driven Mycobacterium tuberculosis Functional Networks for Drug Target Identification

Table 6

Top 10 drug target candidates ranked based on criteria such as high eigenvector (influential) and closeness (central) values, previous identification as a possible target, and essentiality.

UniProt Acc	Gene name	Functional class	Network centrality scores			Previous identification sources
			Eigen	Betweenness	Closeness	Degree	TDR	UniProt	Drugome [36]	Essential [37]
Q7D6Z3	MT2600	Lipid metabolism	0.08369	128207.32	0.37	207	Yes			Yes
P0A5Y6	inhA	Lipid metabolism	0.08216	27379.65	0.36	162	Yes	Yes	Yes
O06934	glf	Cell wall and cell processes	0.08152	67825.15	0.36	172	Yes
Q11141	proC	Intermediary metabolism and respiration	0.08123	57376.99	0.36	165			Yes	Yes
P63562	argC	Intermediary metabolism and respiration	0.08119	51684.48	0.36	163		Yes		Yes
P63629	hom	Intermediary metabolism and respiration	0.08137	50079.08	0.36	171		Yes		Yes
P64328	hemA	Intermediary metabolism and respiration	0.08126	77831.05	0.36	173		Yes		Yes
P0A544	serA	Intermediary metabolism and respiration	0.08133	28205.61	0.36	164		Yes		Yes
P66783	Rv3791	Intermediary metabolism and respiration	0.08162	27347.66	0.35	157		Yes		Yes
O33290	ftsK	Cell wall and cell processes	0.00172	62658.74	0.35	97		Yes		Yes