Flux Analysis of the Trypanosoma brucei Glycolysis Based on a Multiobjective-Criteria Bioinformatic Approach

Figure 3

Schematic representation of Metaboflux. analysis procedure Metaboflux takes two files as input, one SBML file that describes the metabolic network topology and an XML file in Metaboflux format indicating simulation parameters. The first step launches N-analysis core by MPI (Message Passing Interface). Each analysis core solves a constrained optimization problem with a simulated annealing and downhill-simplex. These methods suggest candidate optimal fluxes valuation and submit them to the simulator. The simulator estimates the distribution of the final markings according to theses fluxes valuations and returns the corresponding distance score as a result. These steps are repeated until the optimization procedures converge to one solution.