Maximum Recommended Dosage of Lithium for Pregnant Women Based on a PBPK Model for Lithium Absorption
Figure 2
Concentration profiles in all physiological compartments resulting from a single, time-release 900 mg dosage of lithium drug. Initial lithium concentration in the body is 0 mEq/mL. (a) Profile of drug release pulse. (b) Lithium concentration time courses in the most important compartments for the study, with fetus labeled. (c) Lithium concentration profiles for less critical compartments.
