Maximum Recommended Dosage of Lithium for Pregnant Women Based on a PBPK Model for Lithium Absorption

Table 2

Average and maximum fetal concentrations (mEq/mL) for suggested dosage regimens compared with the pathological case. All dosages are over a 24 hour period.

Dosage regimen	Average fetal concentration (mEq/mL)	Maximum fetal concentration (mEq/mL)
450 mg/900 mg (pathological)	0.965	1.434
300 mg/300 mg/500 mg	0.796	1.021
300 mg/300 mg	0.419	0.570
300 mg/300 mg/300 mg/300 mg	0.867	0.960
400 mg/400 mg/400 mg	0.860	1.019
600 mg/600 mg	0.886	1.141