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Advances in Bioinformatics
Volume 2012, Article ID 839837, 10 pages
Research Article

MicroRNA Response Elements-Mediated miRNA-miRNA Interactions in Prostate Cancer

1Department of Computer Science, University of Calgary, 2500 University Dr. NW, Calgary, AB, Canada T2N 1N4
2Biotechnology Research Center, Palestine Polytechnic University, Hebron, Palestine

Received 21 April 2012; Revised 12 September 2012; Accepted 29 September 2012

Academic Editor: Ramana Davuluri

Copyright © 2012 Mohammed Alshalalfa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary file provides more comparative analysis to compare the MRE mediated miRNA-miRNA interactions produced in this study with correlated miRNA network from miRNA expression and miRNA interactions based on number of common gene targets. Results reveals that the MRE-mediated miRNA-miRNA interaction network is not biased to the correlation between the miRNAs nor it is biased to the number of common target the miRNAs share. This suggests that there is another principle that governs the produced miRNA interaction network. The robustness of the MRE-mediated miRNA-miRNA network was further assessed by using experimentally validated miRNA-target interactions instead of computationally predicted interactions. The results supported the initially observed results that suggest that miRNA-1 is the master regulator of prostate cancer. The diagnostic power of the 11 miRNAs is tested in Taylor prostate data to support that the 11 miRNAs are robust diagnostic biomarkers.

  1. Supplementary Material