Research Article

A Multilevel Gamma-Clustering Layout Algorithm for Visualization of Biological Networks

Figure 5

MLGA applied to (a) A. thaliana biochemical network without signaling effects and regulatory elements. Reactions directly involved in the synthesis of brassinosteroids are highlighted with the red color and direct connections are depicted by red edges. The level 2 cluster, indicated by an arrow, combines the major parts of isoprenoid biosynthesis, resulting from the nonmevalonate pathway. (b) A. thaliana biochemical network including signaling effects and regulatory elements. Reactions directly involved in brassinosteroid and auxin metabolism/signaling are highlighted with red and direct connections are depicted by red edges. Black arrows point to reactions involved in brassinosteroid metabolism/signaling. Green arrows point to reactions involved in auxin metabolism/signaling.
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(a)
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(b)