Utilization of Boron Compounds for the Modification of Suberoyl Anilide Hydroxamic Acid as Inhibitor of Histone Deacetylase Class II Homo sapiens

Table 2

Catalytic site of HDAC class II Homo sapiens enzyme.

Enzyme	Active site
HDAC4	Zn^2+ cofactor with Asp196, His198, and Asp290 residue
HDAC5	Zn^2+ cofactor with Asp870, His872, and Asp964
HDAC6	Zn^2+ cofactor with Cys5, His7, and Cys78
HDAC7	Zn^2+ cofactor with Asp707, His709, and Asp801
HDAC9	Zn^2+ cofactor with Asp820, His822, and Asp914
HDAC10	Zn^2+ cofactor with Asp172, His174, and Asp265