Advances in Bioinformatics / 2014 / Article / Tab 2

Research Article

Utilization of Boron Compounds for the Modification of Suberoyl Anilide Hydroxamic Acid as Inhibitor of Histone Deacetylase Class II Homo sapiens

Table 2

Catalytic site of HDAC class II Homo sapiens enzyme.

EnzymeActive site

HDAC4Zn2+ cofactor with Asp196, His198, and Asp290 residue
HDAC5Zn2+ cofactor with Asp870, His872, and Asp964
HDAC6Zn2+ cofactor with Cys5, His7, and Cys78
HDAC7Zn2+ cofactor with Asp707, His709, and Asp801
HDAC9Zn2+ cofactor with Asp820, His822, and Asp914
HDAC10Zn2+ cofactor with Asp172, His174, and Asp265