Advances in Bioinformatics / 2014 / Article / Tab 7

Research Article

Utilization of Boron Compounds for the Modification of Suberoyl Anilide Hydroxamic Acid as Inhibitor of Histone Deacetylase Class II Homo sapiens

Table 7

Ligand bioavailability.

LigandEgan’s ruleVeber’s ruleBioavability
% (Oral) > 30%% (Oral) > 70%

Nova2 (9058064-6)GoodLow0.030.01
Nova2 (95752-88-8)GoodGood0.850.48
Nova2 (88765-82-6)GoodGood0.850.27
Nova2 (Unique10)GoodGood0.760.27
Nova2 (16876-27-0)GoodGood0.850.48
Nova2 (513246-99-6)GoodGood0.760.27
Nova2 (Unique80)GoodGood0.760.23
Nova2 (279262-23-6)GoodGood0.590.27