Alternate Phosphorylation/O-GlcNAc Modification on Human Insulin IRSs: A Road towards Impaired Insulin Signaling in Alzheimer and Diabetes

Figure 5

Graphical representation of the potential Ser, Thr, and Tyr residues for phosphorylation sites in human IRS-1 and IRS-2. (a) Predicted potential sites for phosphorylation on Ser, Thr, and Tyr residues. The light gray horizontal line shows the threshold for modification potential. The blue, green, and red vertical lines indicate the potential phosphorylated Ser, Thr, and Tyr residues, respectively. This graph was generated by NetPhos 2.0 web based program. (b) Predicted potential sites for phosphorylation on Ser, Thr, and Tyr residues. The light gray horizontal line shows the threshold for modification potential. The blue, green, and red vertical lines indicate the potential phosphorylated Ser, Thr, and Tyr residues, respectively. This graph was generated by NetPhos 2.0 web based program.

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