Local Mutational Pressures in Genomes of Zaire Ebolavirus and Marburg Virus

Table 6

Directions of mutational pressure in coding regions and their fragments for Marburg virus according to the “VVTAK VarInvar” algorithm results. Nucleotide usages in fourfold degenerated invariable and stable sites are compared.

Gene/fragment	NP	VP35	VP40	GP; part 1	GP; part 2	GP; part 3	VP30; part 1	VP30; part 2	VP24	LP
Cytosine usage
Direction
Invariable	11,40%	15,69%	20,83%	16,22%	20,00%	17,65%	16,67%	8,70%	6,25%	5,22%
Stable	17,07%	23,06%	22,19%	25,65%	34,25%	25,15%	25,45%	18,02%	16,69%	14,19%
Guanine usage
Direction
Invariable	14,04%	3,92%	14,58%	8,11%	0,00%	5,88%	0,00%	0,00%	6,25%	6,72%
Stable	15,29%	10,19%	18,57%	14,80%	8,00%	6,23%	0,89%	15,97%	14,15%	12,13%
Uracil usage
Direction	↓	↓	↕	↑	↓	↓	↓	↑	↑	↑
Invariable	32,46%	23,53%	31,25%	35,14%	10,00%	35,29%	25,00%	43,48%	40,63%	45,15%
Stable	33,36%	31,30%	30,77%	31,35%	24,43%	38,39%	36,46%	30,91%	34,40%	38,05%
Adenine usage
Direction
Invariable	42,11%	56,86%	33,33%	40,54%	70,00%	41,18%	58,33%	47,83%	46,88%	42,91%
Stable	34,27%	35,44%	28,46%	28,20%	33,31%	30,23%	37,20%	35,10%	34,76%	35,63%