Research Article

In Silico Investigation of Flavonoids as Potential Trypanosomal Nucleoside Hydrolase Inhibitors

Figure 1

PSP of T. brucei showing key enzymes and transporters. AK = adenosine kinase, APRT = adenine phosphoribosyltransferase, HGPRT = hypoxanthine-guanine phosphoribosyltransferase, XPRT = xanthine phosphoribosyltransferase, and IG-NH = inosine-guanosine nucleoside hydrolase. P1, P2, P1/P2, H2, and H3 are purine base and/or nucleoside transporters [16].