Expressing Redundancy among Linear-Epitope Sequence Data Based on Residue-Level Physicochemical Similarity in the Context of Antigenic Cross-Reaction

Table 2

IEDB Qualitative-Outcome (Q) data on peptide cross-reactivity assays (cf. Figure 5).

#	Q	Assay information				IEDB; Epitope ID	Substitution	Sequence context (with at position of substitution)	Ref.
		Type/MHC class	Parameter measured (cf. IEDB “measurement of” data field)	IEDB ID
				Control reaction	Cross-reaction
1	−	B-cell	Antibody-antigen binding	1370146	1370150	10801	W/Y	DXEDRYYRE	[22]
2	−	T-cell/I	Cytokine release (IFN-)	1340848	1340854	62604	P/A	SYIXSAEKI	[23]
3	−	T-cell/II	Cell proliferation	1646734	1646735	107384	E/D	GEPGIAGFKGXQGPK	[24]
4	−	T-cell/II	Cell proliferation	1660246	1660247	46317	F/A	NTWTTCQSIAXPSK	[25]
5	−	T-cell/II	Cytokine release (IL-4)	1660252	1660258	112245	A/F	NTWTTCQSIAXPSK	[25]
6	−	T-cell/II	Cytokine release (IL-2)	1667060	1667065	68846	K/A	VHFFXNIVTPRTP	[26]
7	−	T-cell/II	Cell proliferation	1667112	1667113	80071	A/K	VHFFXNIVTPRTP	[26]
8	−	T-cell/II	Cell proliferation	1716604	1716614	125569	T/V	SWEGVGVXPDV	[27]
9	−	T-cell/II	Cell proliferation	1716604	1716616	125569	D/N	SWEGVGVTPXV	[27]
10	−	T-cell/II	Cell proliferation	1716605	1716618	125571	V/T	SWEGVGVXPNV	[27]
11	+	T-cell/I	Cytotoxicity	1634784	1634785	103300	S/A	IYXTVAGSL	[28]
12	+	T-cell/I	Cytotoxicity	1634784	1634786	103300	G/S	IYSTVAXSL	[28]
13	+	T-cell/I	Cytotoxicity	1634788	1634789	103298	S/G	IYATVAXSL	[28]
14	+	T-cell/I	Cytotoxicity	1634788	1634790	103298	A/S	IYXTVASSL	[28]
15	+	T-cell/I	Cytotoxicity	1657362	1657364	111964	I/D	YXFAFRDL	[29]
16	+	T-cell/I	Cytokine release (IFN-)	1716442	1716443	125101	I/T	XMIKFNRL	[30]
17	+	T-cell/I	Cytokine release (IFN-)	1340848	1340852	62604	K/D	SYIPSAEXI	[23]
18	+	T-cell/I	Cytokine release (IFN-)	1381750	1381748	37174	D/G	LLXRDSFEV	[31]
19	+	T-cell/I	Cytokine release (IFN-)	1381752	1381753	37392	H/G	LLXRDSFEV	[31]
20	+	T-cell/I	Cytotoxicity	1404705	1404714	61086	S/I	SXIEFARL	[32]
21	+	T-cell/I	Cytotoxicity	1404705	1404715	61086	A/E	SSIEFXRL	[32]
22	+	T-cell/I	Cytotoxicity	1404705	1404716	61086	R/K	SSIEFAXL	[32]
23	+	T-cell/I	Cytotoxicity	1404712	1404719	61088	E/A	SSIEFXRL	[32]
24	+	T-cell/I	Cytotoxicity	1404713	1404721	61085	K/R	SSIEFAXL	[32]
25	+	T-cell/I	Cytokine release (IFN-)	1865529	1865530	98995	T/F	SAPDXRPA	[33]
26	+	T-cell/I	Cytokine release (IFN-)	1865529	1865532	98995	A/L	SAPDTRPX	[33]