A Support Vector Machine Classification of Thyroid Bioptic Specimens Using MALDI-MSI Data

Figure 1

MALDI-MSI data cube. The intensity value of a specific analyte compound is localised as follows: - and -axis represent the spatial coordinates of the 2D digitalised tissue image (a mouse brain is shown in this example); the -axis represents the mass-to-charge (m/z) ratio in the acquired spectra. For each m/z value in the spectrum, a 2D molecular image is computed by colouring the pixels according to the relative abundance (intensity of that m/z value) of the selected compound across the tissue section.