Advances in Bioinformatics / 2016 / Article / Alg 1

Research Article

Multiphase Simulated Annealing Based on Boltzmann and Bose-Einstein Distribution Applied to Protein Folding Problem

Algorithm 1

Pseudocode of classical simulated annealing.
(1) Setting initial temperature ()
(2) Setting final temperature ()
(3) Generate from Initial Solution ()
(5) While () do //Temperature Cycle
(6)  While (stop condition) //Metropolis Cycle
(7)    Generate by applying a perturbation to
(8)    Obtain difference between and
(9)    If (difference ≤ 0) then
(10)     Accept
(11)    else
(12)     Boltzmann Probability =
(13)     If (Boltzmann Probability > random(0, 1)) then
(14)      Accept
(15)     end if
(16)    end if
(17)  end while
(18)  Decrease by a cooling function
(19) end while
(20) Shown better solution ()

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