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Advances in Bioinformatics
Volume 2016, Article ID 8792814, 13 pages
Research Article

Structural Dynamics of Human Argonaute2 and Its Interaction with siRNAs Designed to Target Mutant tdp43

Centre for Bioinformatics, Pondicherry University, Pondicherry 605014, India

Received 27 July 2015; Revised 31 January 2016; Accepted 2 February 2016

Academic Editor: Gilbert Deleage

Copyright © 2016 Vishwambhar Bhandare and Amutha Ramaswamy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary material contains total 7 figures which are highlighted in the manuscript. Supplementary Figures 1 and 2 represent the parameters explaining the structural stability observed during simulations. Supplementary Figures 3 and 4 show the inter domain distance in free Ago2 and site specific interactions between Ago2 and siRNA, respectively. Changes in the secondary structures are given in the supplementary Figure 5. Supplementary Figures 6 and 7 represent the three dimensional conformations.

  1. Supplementary Material