Research Article

In Silico Analysis of SNPs in PARK2 and PINK1 Genes That Potentially Cause Autosomal Recessive Parkinson Disease

Table 1

SNPs within PARK2 gene that affect the structure and function and stability of Parkin protein predicted by SIFT, PolyPhen, and I-mutant tools, respectively.

SNP IDAA
change
SIFT
result
SIFT
score
PolyPhen
result
PolyPhen
score
Protein stabilityI-mutant
score

rs55961220C289GIntolerable0Damaging0.999Decreased9
rs56092260R366WIntolerable0.001Damaging0.999Decreased5