Research Article

Random versus Deterministic Descent in RNA Energy Landscape Analysis

Table 3

Observed local minima: percentage of observed local minima, , relative to found by each descent procedure for the same set of conformations (i.e., last three columns in %); equals the length of sequences and is the number of local minima identified by RNAsubopt and Barriers within the partial energy landscapes.

NumberGeneGradientRandomFirst
lm() lm() lm()

1 PAX7 99 50,861 1.0 63.55 72.64 74.53
2 OXT 99 74,426 1.0 61.74 67.41 72.70
3 GMEB1 113 466,093 2.0 54.54 56.54 57.76
4 LIG3 124 317,284 1.0 42.72 45.50 49.12
5 CBR1 284 643,999 1.5 49.40 48.95 52.07
6 HTR3E 302 533,316 1.5 42.42 44.34 43.55
7 HLA-G 386 906,393 2.5 51.49 52.92 52.99
8 ALDH4A1 400 540,609 1.5 51.06 46.94 51.69
9 MRPL9 407 41,979 1.0 60.44 61.08 61.19
10 AQP5 504 714,812 2.0 58.02 57.98 58.72

Average 53.54 55.43 57.43