Research Article

Random versus Deterministic Descent in RNA Energy Landscape Analysis

Table 5

Increasing energy offset: number of observed local minima and run-time (minutes) for increasing energy offset for gene OXT. Note: randomly sampled from the full partial landscape.

Gradient timeRandom timeFirst timeGradient lm()Random lm()First lm()

14.0 14.80 10.65 11.60 45,656 46,005 48,138
16.0 15.47 10.98 11.48 65,923 70,003 74,939
18.0 15.83 11.61 14.55 87,307 96,911 106,807
20.0 17.27 11.47 14.85 108,334 124,566 141,783
22.0 19.08 11.82 11.78 125,422 150,296 176,904
24.0 21.61 12.17 12.80 138,447 173,275 210,951
26.0 22.28 12.48 12.20 147,261 191,784 241,460