A Novel Framework for Ab Initio Coarse Protein Structure Prediction

Algorithm 1

The pseudocode for hill-climbing controller.

(1)   Hill-climbing controller ;

  Input: current population curP, , Emax free energy

  and opR operator selection probability

  Output: newP new population

(2)   If  Eavg>70% of Emax and Emax<95% of then

(3)   Generate random individual and replace identical

  energy value conformation increase the diver-

  sity of the population

(4)   else

(5)   until termination condition;

(6)   Perform mutation;

(7)   Evaluate new conformation;

(8)   If new conformation better then target confor-

  mation then

(9)   Replace target conformation with new confor-

  mation

(10) End

(11) End

(12) Return the newP