In Silico Characterization and Structural Modeling of Dermacentor andersoni p36 Immunosuppressive Protein

Table 2

Conserved motif 2 of tick p36 proteins mapped as a potential antigenic/binding site region.

Tick species	NCBI accession number	Antigenic score	Conserved Motif 2 location	Antigenic region antigenic peptide tool/SVM Trip tool	Mapped immunogenic segments of Motif 2; Epitopia tool	Mapped Binding sites of Motif 2; Sprint pep tool	Predicted ligands for Motif 2; Coach tool
D. andersoni	AAF03683.1	0.5880	107–127	95–128	IDKGMLSPFNLSATVKFPLIP	IDKGMLSPFNLSATVKFPLIP	Lactose, Glycerol, NAG-(4-1)GAL, Sucrose
R. appendiculatus	JAP81944.1	0.7701	117–137	108–137	IDNGIKTPFHLKAVFSFPITG	IDNGIKTPFHLKAVFSFPITG	-
R. appendiculatus	JAP88013.1	0.7379	113–133	104–133	IDNGIKTPFHLKAVFSFPITG	IDNGIKTPFHLKAVFSFPITG	-
R. appendiculatus	JAP81510.1	0.7258	102–122	94–133	IDDSMYSPFNIMTTVAFPLIG	IDDSMYSPFNIMTTVAFPLIG	B-Octylglucoside
R. appendiculatus	JAP86350.1	0.7072	78–98	74–110	IDYGIYSPFNLVTPVQFPLMG	IDYGIYSPFNLVTPVQFPLMG	Alpha-D-Mannose, Alpha-D-Lactose, B-Octylglucoside

Bold sections: tick p36 conserved region residues mapped as potentially antigenic/binding sites.