Novel Deleterious nsSNPs within MEFV Gene that Could Be Used as Diagnostic Markers to Predict Hereditary Familial Mediterranean Fever: Using Bioinformatics Analysis

Table 1

Damaging or deleterious effect nsSNPs associated variations predicted by various softwares.

Amino Acid Change	SIFT		Polyphen		PROVEAN		SNAP2
	prediction	Score	Prediction	score	Score	Prediction (cutoff= -2.5)	prediction	score
S749Y	DAMAGING	0	PROBABLY DAMAGING	1.000	-3.116	Deleterious	effect	64
F743S	DAMAGING	0	PROBABLY DAMAGING	1.000	-5.563	Deleterious	effect	68
Y741C	DAMAGING	0	PROBABLY DAMAGING	1.000	-6.035	Deleterious	effect	77
F731V	DAMAGING	0	PROBABLY DAMAGING	1.000	-5.159	Deleterious	effect	81
I720T	DAMAGING	0	PROBABLY DAMAGING	1.000	-3.639	Deleterious	effect	58
L709R	DAMAGING	0	PROBABLY DAMAGING	1.000	-4.311	Deleterious	effect	77
V691G	DAMAGING	0	PROBABLY DAMAGING	1.000	-4.667	Deleterious	effect	66
W689R	DAMAGING	0	PROBABLY DAMAGING	1.000	-10.132	Deleterious	effect	89
G668R	DAMAGING	0	PROBABLY DAMAGING	1.000	-6.287	Deleterious	effect	92
V659F	DAMAGING	0	PROBABLY DAMAGING	1.000	-3.811	Deleterious	effect	64
F636C	DAMAGING	0	PROBABLY DAMAGING	1.000	-6.49	Deleterious	effect	79
R461W	DAMAGING	0	PROBABLY DAMAGING	1.000	-5.456	Deleterious	effect	68
H407Q	DAMAGING	0	PROBABLY DAMAGING	1.000	-7.335	Deleterious	effect	41
H407R	DAMAGING	0	PROBABLY DAMAGING	1.000	-7.332	Deleterious	effect	51
H404R	DAMAGING	0	PROBABLY DAMAGING	1.000	-7.349	Deleterious	effect	75
C398Y	DAMAGING	0	PROBABLY DAMAGING	1.000	-10.314	Deleterious	effect	51
C395Y	DAMAGING	0	PROBABLY DAMAGING	1.000	-10.262	Deleterious	effect	19
C395F	DAMAGING	0	PROBABLY DAMAGING	1.000	-10.315	Deleterious	effect	27
C395R	DAMAGING	0	PROBABLY DAMAGING	1.000	-11.074	Deleterious	effect	27
H378Q	DAMAGING	0	PROBABLY DAMAGING	1.000	-5.886	Deleterious	effect	38
H378Y	DAMAGING	0	PROBABLY DAMAGING	1.000	-4.884	Deleterious	effect	45
C375R	DAMAGING	0	PROBABLY DAMAGING	1.000	-8.429	Deleterious	effect	66
L86P	DAMAGING	0	PROBABLY DAMAGING	1.000	-4.1	Deleterious	effect	19