Table 1: Damaging or deleterious effect nsSNPs associated variations predicted by various softwares.

Amino Acid Change SIFTPolyphenPROVEANSNAP2
predictionScorePredictionscoreScorePrediction (cutoff= -2.5)predictionscore

S749YDAMAGING0PROBABLY DAMAGING1.000-3.116Deleteriouseffect64
F743SDAMAGING0PROBABLY DAMAGING1.000-5.563Deleteriouseffect68
Y741CDAMAGING0PROBABLY DAMAGING1.000-6.035Deleteriouseffect77
F731VDAMAGING0PROBABLY DAMAGING1.000-5.159Deleteriouseffect81
I720TDAMAGING0PROBABLY DAMAGING1.000-3.639Deleteriouseffect58
L709RDAMAGING0PROBABLY DAMAGING1.000-4.311Deleteriouseffect77
V691GDAMAGING0PROBABLY DAMAGING1.000-4.667Deleteriouseffect66
W689RDAMAGING0PROBABLY DAMAGING1.000-10.132Deleteriouseffect89
G668RDAMAGING0PROBABLY DAMAGING1.000-6.287Deleteriouseffect92
V659FDAMAGING0PROBABLY DAMAGING1.000-3.811Deleteriouseffect64
F636CDAMAGING0PROBABLY DAMAGING1.000-6.49Deleteriouseffect79
R461WDAMAGING0PROBABLY DAMAGING1.000-5.456Deleteriouseffect68
H407QDAMAGING0PROBABLY DAMAGING1.000-7.335Deleteriouseffect41
H407RDAMAGING0PROBABLY DAMAGING1.000-7.332Deleteriouseffect51
H404RDAMAGING0PROBABLY DAMAGING1.000-7.349Deleteriouseffect75
C398YDAMAGING0PROBABLY DAMAGING1.000-10.314Deleteriouseffect51
C395YDAMAGING0PROBABLY DAMAGING1.000-10.262Deleteriouseffect19
C395FDAMAGING0PROBABLY DAMAGING1.000-10.315Deleteriouseffect27
C395RDAMAGING0PROBABLY DAMAGING1.000-11.074Deleteriouseffect27
H378QDAMAGING0PROBABLY DAMAGING1.000-5.886Deleteriouseffect38
H378YDAMAGING0PROBABLY DAMAGING1.000-4.884Deleteriouseffect45
C375RDAMAGING0PROBABLY DAMAGING1.000-8.429Deleteriouseffect66
L86PDAMAGING0PROBABLY DAMAGING1.000-4.1Deleteriouseffect19