Novel Deleterious nsSNPs within MEFV Gene that Could Be Used as Diagnostic Markers to Predict Hereditary Familial Mediterranean Fever: Using Bioinformatics Analysis

Table 2

Disease effect nsSNPs associated variations predicted by various softwares.

Amino Acid Change	SNP&GO			PHD-SNP			P-Mut
	Prediction	RI	Probability	Prediction	RI	Score	Score	Prediction
S749Y	Disease	1	0.573	Disease	3	0.649	0.67 (85%)	Disease
F743S	Disease	2	0.617	Disease	4	0.696	0.82 (90%)	Disease
Y741C	Disease	6	0.797	Disease	7	0.869	0.61 (83%)	Disease
F731V	Disease	6	0.79	Disease	8	0.899	0.93 (94%)	Disease
I720T	Disease	6	0.811	Disease	5	0.769	0.81 (89%)	Disease
L709R	Disease	3	0.672	Disease	4	0.695	0.66 (85%)	Disease
V691G	Disease	1	0.55	Disease	3	0.675	0.92 (93%)	Disease
W689R	Disease	7	0.841	Disease	8	0.924	0.93 (94%)	Disease
G668R	Disease	6	0.778	Disease	7	0.84	0.93 (94%)	Disease
V659F	Disease	6	0.805	Disease	7	0.84	0.82 (90%)	Disease
F636C	Disease	6	0.809	Disease	7	0.86	0.60 (82%)	Disease
R461W	Disease	3	0.644	Disease	1	0.572	0.63 (84%)	Disease
H407Q	Disease	6	0.788	Disease	4	0.705	0.79 (89%)	Disease
H407R	Disease	5	0.769	Disease	3	0.673	0.86 (91%)	Disease
H404R	Disease	5	0.744	Disease	5	0.734	0.80 (89%)	Disease
C398Y	Disease	7	0.864	Disease	8	0.912	0.86 (91%)	Disease
C395Y	Disease	7	0.864	Disease	8	0.912	0.91 (93%)	Disease
C395F	Disease	7	0.859	Disease	8	0.914	0.92 (94%)	Disease
C395R	Disease	7	0.842	Disease	8	0.892	0.92 (94%)	Disease
H378Q	Disease	4	0.714	Disease	4	0.698	0.88 (92%)	Disease
H378Y	Disease	5	0.732	Disease	5	0.728	0.80 (89%)	Disease
C375R	Disease	6	0.784	Disease	6	0.822	0.92 (94%)	Disease
L86P	Disease	5	0.729	Disease	6	0.801	0.51 (79%)	Disease