Table 2: Disease effect nsSNPs associated variations predicted by various softwares.

Amino Acid ChangeSNP&GOPHD-SNP P-Mut
PredictionRIProbabilityPredictionRIScoreScorePrediction

S749YDisease10.573Disease30.6490.67 (85%)Disease
F743SDisease20.617Disease40.6960.82 (90%)Disease
Y741CDisease60.797Disease70.8690.61 (83%)Disease
F731VDisease60.79Disease80.8990.93 (94%)Disease
I720TDisease60.811Disease50.7690.81 (89%)Disease
L709RDisease30.672Disease40.6950.66 (85%)Disease
V691GDisease10.55Disease30.6750.92 (93%)Disease
W689RDisease70.841Disease80.9240.93 (94%)Disease
G668RDisease60.778Disease70.840.93 (94%)Disease
V659FDisease60.805Disease70.840.82 (90%)Disease
F636CDisease60.809Disease70.860.60 (82%)Disease
R461WDisease30.644Disease10.5720.63 (84%)Disease
H407QDisease60.788Disease40.7050.79 (89%)Disease
H407RDisease50.769Disease30.6730.86 (91%)Disease
H404RDisease50.744Disease50.7340.80 (89%)Disease
C398YDisease70.864Disease80.9120.86 (91%)Disease
C395YDisease70.864Disease80.9120.91 (93%)Disease
C395FDisease70.859Disease80.9140.92 (94%)Disease
C395RDisease70.842Disease80.8920.92 (94%)Disease
H378QDisease40.714Disease40.6980.88 (92%)Disease
H378YDisease50.732Disease50.7280.80 (89%)Disease
C375RDisease60.784Disease60.8220.92 (94%)Disease
L86PDisease50.729Disease60.8010.51 (79%)Disease